NCT05940935 - The Relationship of Developing Metabolic Acidosis With Antiepleptic Drugs in Craniotomy Operations | Crick

Overview

The relationship of developing metabolic acidosis with antiepleptic drugs in craniotomy operations

Metabolic acidosis is a life-threatening complication in the perioperative, intraoperative and postoperative period. It can cause decreased cardiac output, electrolyte imbalance, surgical bleeding and neurological complications, even coma and death in surgical patients. Topiramate and zonisamide are sulfonamide derivative compounds used in the treatment of epilepsy. It has been shown in studies that both drugs have a strong inhibition of carbonic anhydrase enzyme. Recent case reports suggest that both drugs may cause metabolic acidosis by lowering serum bicarbonate levels in some patients. Aim in this study is to determine the relationship between preoperative, intraoperative and postoperative metabolic acidosis and to emphasize the importance of anesthesia management in patients who have undergone craniotomy and use antiepileptic drugs.

Study Type

OBSERVATIONAL

Enrollment

35

Conditions

Metabolic Acidosis Antiepileptic Drugs Craniotomy Anesthesia Management

Interventions

Arterial Blood Gas Base DeficitPROCEDURE

The base deficit values in the preoperative, intraoperative and postoperative blood gases taken from the patients and the presence and severity of metabolic acidosis were evaluated. Metabolic acidosis severity was defined by base deficit levels: mild from -3 to -5, moderate from -5 to -10, and severe metabolic acidosis below -10.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing intracranial surgery with craniotomy and using antiepileptic drugs * ASA I-III * Patients undergoing elective surgery Exclusion Criteria: * Patients with a surgical procedure time of more than 5 hours * Patients who received more than 2 units of blood transfusion during the operation * Patients taking other drugs that can cause metabolic acidosis * Patients with diabetes mellitus, diabetes insipidus, hepatic or renal disease

Locations (1)

Trakya University

Edirne, Centrum, Turkey (Türkiye)

Outcomes

Primary Outcomes

Preoperative Metabolic Acidosis

The base deficit values in the preoperative, intraoperative and postoperative blood gases taken from the patients and the presence and severity of metabolic acidosis were evaluated. Metabolic acidosis severity was defined by base deficit levels: mild from -3 to -5, moderate from -5 to -10, and severe metabolic acidosis below -10.

Time frame: Baseline

Intraoperative Metabolic Acidosis

The base deficit values in the preoperative, intraoperative and postoperative blood gases taken from the patients and the presence and severity of metabolic acidosis were evaluated. Metabolic acidosis severity was defined by base deficit levels: mild from -3 to -5, moderate from -5 to -10, and severe metabolic acidosis below -10.

Time frame: during the operation

Postoperative Metabolic Acidosis

The base deficit values in the preoperative, intraoperative and postoperative blood gases taken from the patients and the presence and severity of metabolic acidosis were evaluated. Metabolic acidosis severity was defined by base deficit levels: mild from -3 to -5, moderate from -5 to -10, and severe metabolic acidosis below -10.

Time frame: Day 1