Microbiome Development in the Early Healing of Osseointegrated Implants

Inclusion Criteria: * Males and females, at least 18 years old * Partially edentulous patients rehabilitated with at least two dental implants (canine to molars) placed in two different quadrants in healed sites (3 months post extraction) as part of the previous RCT. * Subject must have voluntarily signed the informed consent, are willing and able to attend scheduled follow-up visits, and agree that the encoded data will be collected and analyzed. For the current investigation, only those participants treated in the University Complutense of Madrid (n=30) will be selected Exclusion Criteria: * Any contraindications for oral surgical procedures * Dental implant placement contraindicated according to Instructions for Use (IFU) * Subjects with inadequate oral hygiene (FMPS ≥ 20%) * Subjects who are currently heavy smokers (defined \>10 cigarettes per day or \>1 cigar per day) or who use chewing tobacco * Subjects with drug or alcohol abuse * Patients requiring soft tissue and bone grafting procedures * Patients having had soft tissue grafting procedures within the last 3 months and bone grafting procedures within the last 6 months in the region where a study implant is planned * Keratinized soft tissue height of less than 2 mm where a study implant is planned * Inadequate bone volume * Severe bruxism or clenching habits * Woman who are pregnant or planning to become pregnant at any point during the study duration. * Patients who have systemic factors that could interfere with the healing process of either bone or soft tissue or the osseointegration process (e.g. bone metabolism disturbances, uncontrolled diabetes mellitus, anticoagulation drugs/ hemorrhagic diatheses) * Patients with local factors that could interfere with the healing process, such as untreated periodontal diseases, acute infection of implant site, temporomandibular joint disorders, treatable pathologic diseases of the jaw and changes in the oral mucosa) * Conditions or circumstances, in the opinion of the investigator, which would prevent completion of study participation or interfere with analysis of study results, such as history of non-compliance, or unreliability. Patients will be informed verbally and in written paper of the visit at 2-year post-implant placement, and will need to sign a new informed consent for this evaluation.