This is a prospective, placebo controlled study, examining the effects of dietary supplement's effects on cognition and confirming safety.
The objective of this prospective, placebo controlled, double-blinded, parallel-group study is to examine the effects of dietary supplement containing grape juice extract, astaxanthin, and vitamin E over 12 week consumption on cognitive performance and self report results based on questionnaires. Furthermore, an evaluation of general well-being, mood, markers of oxidative stress, neurogenesis (BDNF), eye health, skin health, skin carotenoid concentrations, and safety measurements will be assessed.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
110
2 softgels per day
2 softgels per day
Clinical Research Australia
Duncraig, Western Austrailia, Australia
RECRUITINGChange in working memory
Determine change in working memory as measured by the Numeric Working Memory Test
Time frame: Baseline and Week 12
Change in Working memory by Corsi Block tasks
Determine if working memory change by doing Corsi blocks task
Time frame: Baseline and Week 12
Change in verbal learning and memory
Determine if verbal learning and memory change using total score on Rey Auditory Verbal Learning test trials 1 to 5
Time frame: Baseline and Week 12
Change in episodic memory
Determine change in episodic memory as measured by Rey Auditory Verbal Learning Test delayed recall and computerized location learning task
Time frame: Baseline and Week 12
Change in accuracy of attention
Determine change inaccuracy of attention as measured by the choice reaction time and digit vigilance task (percent correct)
Time frame: Baseline and Week 12
Change in the Everyday Memory
Determine the change in the Everyday Memory Questionnaire total score
Time frame: Baseline, Week 4, Week 8, Week 12
Change in the Perceived Stress score
Determine the change in the Perceived Stress Questionnaire total score
Time frame: Baseline, Week 4, Week 8, Week 12
Change in the World Health Organization score
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Determine the change in the World Health Organization-5 (WHO-5) score
Time frame: Baseline, Week 4, Week 8, Week 12
Change in oxidative stress marker
Determine change in plasma malondialdehyde
Time frame: Baseline and Week 12
Change in plasma Tumor Necrosis Factor-alpha concentrations
Determine change in plasma Tumor Necrosis Factor concentrations
Time frame: Baseline and Week 12
Change in marker of inflammation in the plasma
Determine the change in the plasma marker (interleukin-6-alpha concentrations
Time frame: Baseline and Week 12
Change in plasma Brain-derived neurotropic factor concentrations
Determine the change in plasma Brain-derived neurotropic factor concentrations
Time frame: Baseline and Week 12
Change in Skin Carotenoid Score
Determine the change in Skin Carotenoid Scores using Raman spectroscopy (BioPhotonic Scanner)
Time frame: Baseline and Week 12