Adding Desmopressin to Tamsulosin for Treatment of BPH

Mansoura University160 enrolled

Overview

In this study investigators will add desmopressin for treatment of patients with benign prostatic hyperplasia and nocturnal polyurea

Investigators will give a group of patients tamsulosin and desmopressin and the other group will take tamsulosin and placepo and compare the outcome regarding symptoms of being prostatic hyperplasia especially nocturia and the effect on nocturnal polyurea in patients

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

160

Conditions

Nocturnal Polyurea in Patients With BPH

Interventions

Desmopressin AcetateDRUG

This arm will receive tamsulosin and desmopressin acetate daily a

PlaceboDRUG

This arm will receive tamsulosin and placebo

Eligibility

Sex: MALEMin age: 50 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Men with BPH Age more than 50years Patients with nocturia (2voids per night or More) Patients with nocturnal polyurea (urine volume More than 33%of urine allover the day) IPSS more than 12 Obstructed flow curve Post voiding residual less than 150 Exclusion Criteria: * men with BPH with : Acute urine retention Neurogenic bladder dysfunction Cardiovascular disease Hyponatremia Urethral stricture Bladder calculi Prostate cancer

Locations (1)

Urology and nephrology center

Al Mansurah, Outside U.S./Canada, Egypt

RECRUITING

Outcomes

Primary Outcomes

Change of symptoms and nocturia disappears or improve

Investigators will compare symptoms in the pretreatment period and follow up symptoms following treatment and record the outcome

Time frame: Follow up for 6 months

Central Contacts

Ahmed Azmy, Resident

CONTACT

+20 01010623936 dr.a.azmy93@gmail.com

Data from ClinicalTrials.gov

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