The aim of this study was to determine whether grape seed extract (GSE) supplementation could reduce the blood pressure (BP) in response to static exercise and post exercise muscular ischemia (PEMI) in normotensive young adults. In 12 healthy subjects (7 male and 5 female, 24.6±3.4 yr), we compared acute effect of both GSE (600 mg) and placebo (PL: 600 mg) on changes from rest in systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (CO), and total peripheral resistance (TPR) during static exercise (SE) and PEMI. Subjects completed 2 min of SE at 30% of maximal voluntary contraction (MVC) followed by 2 min of PEMI.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
12
Acute effect of dietary supplementation with GSE on hemodynamic responses during static exercise and muscle metaboreflex and during cycling exercise.
California Baptist University
Riverside, California, United States
Systolic blood pressure (mmHg) by sphygmomanometer
Measured from the brachial artery
Time frame: 24 hours
Diastolic blood pressure (mmHg) by sphygmomanometer
Measured from the brachial artery
Time frame: 24 hours
Mean arterial pressure (mmHg)
calculated (MAP = (SBP-DBP)/3 + DBP
Time frame: 24 hours
Heart rate (bpm)
measured using Physio Flow (non-invasive device)
Time frame: 24 hours
Stroke volume (ml)
measured using Physio Flow (non-invasive device)
Time frame: 24 hours
Cardiac output (l/min)
calculated: HR (bpm) x SV (ml)
Time frame: 24 hours
Total peripheral resistance (mmHg/l/min)
calculated: MAP (mmHg) / CO (l/min)
Time frame: 24 hours
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