Pre-operative 5% Dextrose Infusion & PONV

Cairo University105 enrolled

Overview

With this study, we aim to compare the efficacy of pre-operative dextrose-containing fluid infusion with other fluid for the prevention of PONV in middle ear surgeries.

We hypothesized that maintenance of stable level of blood glucose in addition to adequate hydration through preoperative intravenous dextrose 5% infusion will have a rule in decreasing the incidence and severity of PONV; as it reduces insulin resistance and decreases gastric acid secretion; which may contribute to PONV.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

105

Conditions

Nausea, Postoperative

Interventions

Dextrose 5%, normal salineDIETARY_SUPPLEMENT

Decrease fasting hours

Eligibility

Sex: ALLMin age: 20 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * ASA physical status I and ll. * Patients undergoing middle ear surgeries, mastoidectomy, or tympanoplasty Exclusion Criteria: * history of dependence or use of antiemetics * history of motion sickness * presence of psychiatric illness * pregnant and lactating women * cardiovascular disorders (Ischemic heart diseases, congestive heart failure and valvular diseases) * Diabetic patients

Locations (1)

Faculty of Medicine- Cairo University

Cairo, Egypt

Outcomes

Primary Outcomes

PONV

incidence

Time frame: 24 hours

Data from ClinicalTrials.gov

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