Safety and Efficacy of High Flow Nasal Canula in Patients With Mild Hypercapnia

Mansoura University30 enrolled

Overview

Evaluate safety and efficacy of application ( high flow nasal canula) in cases with mild hypercapnia, included 30 patients who were hospitalized in Mansoura University chest department with mild Hypercapnia (Pco2 range 45-60 mmhg and power of hydrogen not less 7.30) of different pulmonary disease categories (Chronic obstructive pulmonary disease acute exacerbation, pneumonia, Interstitial lung diseases, etc).

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Hypercapnia

Interventions

high flow nasal canulaDEVICE

administration of high flow nasal canula at initial flow 35 liters per minute and Fio2 (fraction of inspired oxygen of 50%) with titration to reach oxygen saturation of 88-92%.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients with mild Hypercapnia Exclusion Criteria: * Excluded cases had age less than 18 years or pediatric group . * patients with their mental state altered, confused, comatose, severe agitation or non cooperative * Cases with moderate or severe Hypercapnia * cases in need for immediate invasive mechanical ventilation * cases with respiratory rate more than 35 breath per minute. * cases with Respiratory exhaustion , fatigue , excess use of respiratory accessory muscles * Shock , hemodynamic instability, post arrest cases, * cases with facial trauma or severe nasal deformity, * Patients with sleep breathing disorders or upper airway obstruction * patients with history of home ventilation prior admission

Locations (1)

Mansoura University Hospitals

Al Mansurah, Dakahlia Governorate, Egypt

Outcomes

Primary Outcomes

Arterial Blood Gases changes

The primary outcome was concerned about changes in Arterial Blood Gases in first 24 h after admission and the same changes 48 h after admission.

Time frame: 48 hours

Secondary Outcomes

Number of participants in need for ventilation

Secondary outcome was concerned about need to non invasive mechanical ventilation or invasive mechanical ventilation.

Time frame: 7 days

Data from ClinicalTrials.gov

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