A Study of PM1015 in Patients With Advanced Solid Tumors

Inclusion Criteria: * Volunteer to participate in clinical trials; Fully understand the test and voluntarily sign the informed consent; Willing to follow and able to complete all test procedures; * No gender limit, aged between 18 and 75 years (including boundary values); * Subjects with histologically or cytologically confirmed advanced malignant solid tumors who have failed standard treatment, have no standard treatment options, or are not currently eligible for standard treatment; * Adequate organ function, as defined below: 1. Blood system (in the absence of blood transfusion, granulocyte colony stimulating factor, or other medical support within 14 days prior to initiation of trial therapy) : neutrophil count (ANC) \>= 1.5 x 10\^9 /L; Platelet count (PLT) \>= 100 x 10\^9 /L; Hemoglobin (Hb) \>= 90 g/L; 2. Liver function: total bilirubin (TBIL) \<= 1.5 x upper limit of normal (ULN), subjects with liver metastasis or liver cancer \<= 2 x ULN; Subjects with Gilbert disease should be \<= 3 x ULN; Aspartate aminotransferase (AST), alanine aminotransferase (ALT) \<= 2.5 x ULN (subjects with liver metastasis or liver cancer: \<= 3 x ULN); 3. Renal function: serum creatinine \<= 1.5 x ULN or creatinine clearance \>= 50 mL/min (Cockcroft-Gault formula: \[(140 - age) x body weight (kg) x 0.85 (for females only)\] / \[72 x creatinine (mg/dL)\]; (Creatinine unit conversion: 1 mg/dL = 88.4 μmol/L); Qualitative urine protein \<= 1+; If the qualitative urine protein \>= 2+, 24h urine protein quantitative examination is required; if the quantitative urine protein \< 1g, it is acceptable; 4. Coagulation function: International standardized ratio (INR) and activated partial thrombin time (APTT) should be less than 1.5 x ULN; Subjects with liver metastasis or liver cancer should be \<= 2 x ULN; * Physical status: The Eastern Cooperative Oncology Group (ECOG) physical status score was 0-1; * Expected survival \>= 12 weeks; * Dose escalation test: According to RECIST version 1.1, there is at least one evaluable tumor lesion; Initial dose extension test: At least one measurable tumor lesion according to RECIST version 1.1; (Tumor lesions located in the area of previous radiotherapy or other local regional treatment sites are generally not considered as measurable lesions, unless the lesions show definite progression or persist 3 months after radiotherapy; Not accept only bone metastases or only central nervous system metastases as measurable lesions); * All subjects should undergo a fresh tumor lesion biopsy during the screening period (No bone biopsy; Biopsy is also not acceptable in subjects with a single target lesion for biopsy); If biopsy is not possible, subjects should provide formalin-fixed-paraffin-embedded (FFPE) tumor samples from the nearest (up to 24 months) to the start of the trial for biomarker analysis; If the subject is unable to provide specimens that meet the above requirements due to special reasons, the subject may participate in screening with the consent of the sponsor's medical monitor; * A fertile female subject has a negative serum-pregnancy result within 7 days prior to the start of the trial treatment and is willing to abstain from sex or use a medically approved highly effective contraceptive method (e.g. IUD, condom) from the date of signing the informed consent to 6 months after the end of the final medication; * Male subjects are willing to abstain from sex or use a medically approved highly effective contraceptive method for 6 months from the date of signing the informed consent, and do not donate sperm during this period. Exclusion Criteria: * History of severe allergic disease, allergy to serious drugs (including unmarketed test drugs) or known allergy to any component of the test drug; * Previous treatment with adenosine inhibitors (such as anti-CD73, anti-CD39, or anti-A2aR); * Received an unmarketed investigational drug or treatment within 4 weeks prior to initiation of the trial treatment, or is still within the drug's 5 half-lives (if known), whichever is longer; * The adverse reactions of previous antitumor therapy have not recovered to the NCI-CTCAE V5.0 rating \<= grade 1 (except for toxicities without safety risks as determined by the researchers, such as hair loss, grade 2 peripheral neurotoxicity, stable hypothyroidism after hormone replacement therapy, etc.); * Received the following treatments or drugs before starting the trial therapy: 1. Major organ surgery (excluding needle biopsy) or major trauma or invasive dental procedures within 4 weeks before the initiation of trial treatment, or the need for elective surgery during the trial; 2. Within 4 weeks prior to initiation of trial therapy, received chemotherapy, radical/extensive radiotherapy, endocrine therapy, biological therapy (such as tumor vaccine, cytokine), immune checkpoint agonists (such as 4-1BB agonists, OX40 agonists) or immune checkpoint inhibitors (such as anti-PD-1, anti-PD-L1, anti-CTLA-4, anti-LAG-3) and other anti-tumor therapy; Received nitrosourea and mitomycin C within 6 weeks prior to initiation of treatment; Received oral fluorouracil, small-molecule targeted drugs, and traditional Chinese medicine with anti-tumor indications within 2 weeks before the start of the experimental treatment; Received palliative radiotherapy for vital organs (such as liver, brain, lung, etc.) within 7 days prior to the start of trial therapy; 3. Received systemic glucocorticoid (prednisone \>10 mg/ day or equivalent dose of the same drug) or other immunosuppressant therapy within 14 days prior to the initial use of the test drug; Except in the following cases: treatment with topical, ocular, intra-articular, intranasal, and inhaled corticosteroids; Short-term use of glucocorticoids for preventive treatment (e.g. to prevent hypersensitivity to contrast media); 4. Have received live attenuated vaccine within 4 weeks before the first use of the trial drug; * History of immune deficiency, including HIV antibody positive test; * Syphilis antibody positive; * HBsAg or HBcAb positive, HBV-DNA \> 500 IU/mL or lower limit of detection in test center (only when lower limit of detection in test center is higher than 500 IU/mL); HCV antibody positive and HCV-RNA higher than the lower limit of test center detection; 9. Subjects with brain parenchymal metastasis or meningeal metastasis with clinical symptoms were judged by the researchers to be unsuitable for inclusion; * Active infection; * Subjects with active or previous autoimmune diseases with potential recurrence (e.g. systemic lupus erythematosus, rheumatoid arthritis, vasculitis, etc.), except clinically stable autoimmune thyroid disease and type I diabetes; * Currently with uncontrollable pleural, pericardial and abdominal effusion; * A history of severe cardiovascular and cerebrovascular diseases, including but not limited to: 1. Severe cardiac rhythm or conduction abnormalities, such as ventricular arrhythmias requiring clinical intervention, degree Ⅱ-Ⅲ atrioventricular block; 2. The mean QT interval (QTcF) corrected by Fridericia was \>450 ms for male and \> 470 ms for female; 3. Acute coronary syndrome, congestive heart failure, aortic dissection, stroke, or other grade 3 or higher cardiovascular and cerebrovascular events occurred within 6 months before trial administration began; 4. New York Heart Association Cardiac Function Grade \>= II, or left ventricular ejection fraction (LVEF) \< 50%; 5. Clinically uncontrolled hypertension (systolic blood pressure \>= 160 mmHg and/or diastolic blood pressure \>=100 mmHg); 6. The presence of any factors that increase the risk of prolonged QTc or arrhythmia, such as heart failure, hypokalemia, congenital long QT syndrome, or the use of any concomitant drugs known to prolong the QT interval; * Previous history of allogeneic organ transplantation or allohematopoietic stem cell transplantation; * A known history of alcohol abuse, psychotropic substance abuse or drug use; * Subjects with mental disorders or poor compliance; * Pregnant or lactating subjects; * According to the investigator's judgment, the basic condition of the subject may increase the risk of receiving the trial drug treatment, or cause confusion in the interpretation of toxic reactions and AEs; * Other circumstances in which the investigator did not consider participation in the trial appropriate.