We designed this study to examine whether COVID-19 infection could lead to retinal and choroidal microvascular involvement in school-age children (6-18 years) in a pandemic peak in China.
This is an observational case-control study. One hundred school-age children who visited the Department of Ophthalmology at Guangzhou First People's Hospital in China from February 1, 2023 to March 31, 2023 were included in this study. Eighty children with COVID-19 infection were included in the case group. Controls without COVID-19 infection were matched to COVID-19 infection cases by a ratio of 1:4 using frequency matching on age and gender. The primary end point of this study is the retinal and choroidal microvascular changes in school-age children during the COVID-19 pandemic. Secondary endpoint is the
Study Type
OBSERVATIONAL
Enrollment
100
Guangzhou First People's Hospital
Guangzhou, Guangdong, China
Macular and peripapillary blood perfusion density
The blood flow density represents the proportion of the blood flow signal area in the scanning area to the overall area, expressed in units of mm-1, which can show the blood vessel perfusion and circulation.
Time frame: 5 minutes
Macular and peripapillary retinal thickness
Macular fovea and peripheral retinal thickness, retinal thickness around the optic nerve
Time frame: 3 minutes
Fundus lesions
Such as fundus hemorrhage, exudation, vascular tortuous expansion, etc.
Time frame: 2 minutes
Vascular distribution shape in macular area
The measurement parameters of the foveal avascular zone include area, perimeter and non-circular index
Time frame: 2 minutes
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