Comparative Responses to 15 Different Antidepressants in Major Depressive Disorder

Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital73,336 enrolled

Overview

Achieving results from RCTs with high internal and external validity is a major challenge within psychiatry due to the nature of psychiatric illnesses. The Investigators will conduct a "real world" naturalistic nation-wide population-based longitudinal register linkage study comparing long-term responses to all kinds of antidepressants in patients with major depressive disorder emulating a randomized trial.

Study Type

OBSERVATIONAL

Enrollment

73,336

Conditions

Major Depressive Disorder

Interventions

AntidepressantDRUG

Treatment with an antidepressant according to Danish register data.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: All patients with a psychiatric contact (as inpatients or outpatients) in the period from 1995 to 2018 with a first main index diagnosis of a single depressive episode or recurrent depressive disorder (ICD-10 code: F32-F33.9) with an outpatient purchase of an antidepressant after the depression diagnosis (N=73.336). Exclusion Criteria: None.

Locations (1)

Psychiatric Center Copenhagen

Copenhagen, Denmark

Outcomes

Primary Outcomes

Response

Response was defined as continuous monotherapy with an antidepressant drug without switch to or add-on of another antidepressant drug, an antipsychotic drug or lithium or hospitalization with a main ICD-10 diagnosis of a single depressive episode or recurrent depressive disorder .

Time frame: 2 years

Data from ClinicalTrials.gov

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