Neurological Blood-based Biomarkers and Cognitive Disorders in Critically Ill Survivors.

University of Liege30 enrolled

Overview

Cognitive disorders are common after intensive care. Currently, their diagnosis is based on clinical tests. The investigators plan to study the relationship between different neurological blood biomarkers (cytokines, S100β protein, neuron specific enolase, total Tau protein and neurofilament light chain) and the occurrence of cognitive disorders during the three months following intensive care discharge.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Intensive Care Unit Syndrome Post-intensive Care Syndrome Cognitive Disorder

Interventions

Blood analysisOTHER

Blood analysis for neurological biomarkers measurements

Cognitive testsOTHER

Questionnaires assessing cognitive function

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Anticipated ICU stay of at least 7 days for sepsis, acute respiratory distress syndrome, severe burns * French speaking Exclusion Criteria: * hearing loss or blindness * mental retardation * known cognitive disorders or dementia * ICU admission for neurological disease * refusal

Locations (1)

University Hospital of Liège

Liège, Belgium

RECRUITING

Outcomes

Primary Outcomes

Blood neurological biomarkers levels

Measurement of blood levels of S100β protein

Time frame: ICU Admission

Blood neurological biomarkers levels

Measurement of blood levels of S100β protein

Time frame: day 3 after ICU admission

Blood neurological biomarkers levels

Measurement of blood levels of S100β protein

Time frame: day 7 after ICU admission

Blood neurological biomarkers levels

Measurement of blood levels of S100β protein

Time frame: day 14 after ICU admission

Blood neurological biomarkers levels

Measurement of blood levels of S100β protein

Time frame: 3 months after ICU discharge

Blood neurological biomarkers levels

Measurement of blood levels of neuron specific enolase

Time frame: ICU Admission

Blood neurological biomarkers levels

Measurement of blood levels of neuron specific enolase

Time frame: day 3 after ICU admission

Blood neurological biomarkers levels

Measurement of blood levels of neuron specific enolase

Time frame: day 7 after ICU admission

Blood neurological biomarkers levels

Measurement of blood levels of neuron specific enolase

Central Contacts

Anne-Françoise Rousseau, MD, PhD

CONTACT

+3243234776 afrousseau@chuliege.be

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.

Time frame: day 14 after ICU admission

Blood neurological biomarkers levels

Measurement of blood levels of neuron specific enolase

Time frame: 3 months after ICU discharge

Blood neurological biomarkers levels

Measurement of blood levels of total Tau protein

Time frame: ICU Admission

Blood neurological biomarkers levels

Measurement of blood levels of total Tau protein

Time frame: day 3 after ICU admission

Blood neurological biomarkers levels

Measurement of blood levels of total Tau protein

Time frame: day 7 after ICU admission

Blood neurological biomarkers levels

Measurement of blood levels of total Tau protein

Time frame: day 14 after ICU admission

Blood neurological biomarkers levels

Measurement of blood levels of total Tau protein

Time frame: 3 months after ICU discharge

Blood neurological biomarkers levels

Measurement of blood levels of neurofilament light chain

Time frame: ICU Admission

Blood neurological biomarkers levels

Measurement of blood levels of neurofilament light chain

Time frame: day 3 after ICU admission

Blood neurological biomarkers levels

Measurement of blood levels of neurofilament light chain

Time frame: day 7 after ICU admission

Blood neurological biomarkers levels

Measurement of blood levels of neurofilament light chain

Time frame: day 14 after ICU admission

Blood neurological biomarkers levels

Measurement of blood levels of neurofilament light chain

Time frame: 3 months after ICU discharge

Cognitive disorders assessment (global assessment)

Administration of the MOCA questionnaire (Montreal Cognitive Assessment) : scoring from 0 to 30, the highest score meaning the better cognitive outcome)

Time frame: the day after ICU discharge

Cognitive disorders assessment (global assessment)

Administration of the MOCA questionnaire (Montreal Cognitive Assessment) : scoring from 0 to 30, the highest score meaning the better cognitive outcome)

Time frame: 3 months after ICU discharge

Memory disorder assessment

Administration of the California Verbal Learning Test: a Z-score will be used to score this item

Time frame: 3 months after ICU discharge

Memory disorder assessment

Administration of the Brief Visuospatial Memory Test (a Z-score will be used to score this item)

Time frame: 3 months after ICU discharge

Speed of information processing assessment

Administration of the Ways IV test (a Z-score will be used to score this item)

Time frame: 3 months after ICU discharge

Executive function assessment

Administration of the Trail Making Test (a Z-score will be used to score this item)

Time frame: 3 months after ICU discharge

Memory disorder assessment

Administration of the Reading Span (working memory) test (a Z-score will be used to score this item)

Time frame: 3 months after ICU discharge

Executive function assessment

Administration of the Stroop Color and Word Test (a Z-score will be used to score this item)

Time frame: 3 months after ICU discharge

Executive function assessment

Administration of the Go/No-go test (a Z-score will be used to score this item)

Time frame: 3 months after ICU discharge