A Study of Changes in Heart Function and Blood Flow in People Receiving Anesthesia

Memorial Sloan Kettering Cancer Center250 enrolled

Overview

The purpose of this study is to understand changes in heart function (how the heart pumps blood) and blood flow in people who receive general anesthesia during surgery. The researchers are particularly interested in the heart function and blood flow changes in people who experience low blood pressure (hypotension) after receiving anesthesia.

Study Type

OBSERVATIONAL

Enrollment

250

Conditions

Anesthesia

Interventions

EchocardiographyDIAGNOSTIC_TEST

Echocardiography and Clearsight BP measurements before, immediately after anesthesia induction and after intubation (for 20 min)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients ≥ 18 years of age requiring general anesthesia for surgery * Intubation required for anesthetic management / surgery * Anticipated prep time before incision of 20 minutes * Baseline MAP \>70mmHg Exclusion Criteria: * History of coronary artery disease * History of cardiac disease (e.g., HTN, arrythmias, valvular and structural abnormalities) * History of peripheral artery occlusive disease * Beta-blocker use * Anti-hypertensive medication use * Patients with epidural, spinal, paravertebral, serratus blocks preoperatively * Patients requiring rapid sequence induction (where intubation occurs concurrently with induction) * Emergency surgery

Locations (1)

Memorial Sloan Kettering Cancer Center (All protocol activites)

New York, New York, United States

RECRUITING

Outcomes

Primary Outcomes

The proportion of patients with post-induction hypotension (PIH)

summarize the distributions of the echocardiography parameter values (pre-load LVEDd(cm), after-load LVEDs(cm), other measures \[e.g., contractility (EF %) and structural abnormalities\]) across each timepoint among patients with and without PIH

Time frame: up to 20-mins after anesthesia induction.

Central Contacts

Anahita Dabo-Trubelja, MD

CONTACT

212-639-3279 daboa@mskcc.org

Gregory Fischer, MD

CONTACT

212-639-2581

Data from ClinicalTrials.gov

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