A Study of Spoken Language in Mania

N/ACompletedNCT05956340

Mayo Clinic17 enrolled

Overview

This research is being done to find if there are changes with voice and speech during episodes of mania.

Study Type

INTERVENTIONAL

Allocation

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Manic Episode Bipolar I Disorder

Interventions

Research interviewBEHAVIORAL

Research interview to capture speech data with high quality cardioid headset microphone

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Provision of informed consent before any study procedures are performed * English speaker * Documented clinical diagnosis for Bipolar I Disorder * Undergoing hospitalization, or boarding in the Emergency Department, for mania as determined by primary clinical staff Exclusion Criteria: * Positive urine drug screen for amphetamines or cocaine. * Expressing paranoid delusions regarding electronic surveillance. * Documented clinical diagnosis of developmental delay. * Currently involuntarily hospitalized. * Deemed at risk for aggression. * Failure to comprehend study objectives via comprehension questionnaire. * Individuals who have a guardian and are unable to consent for themselves. * Current communicable disease requiring isolation.

Locations (1)

Mayo Clinic Minnesota

Rochester, Minnesota, United States

Outcomes

Primary Outcomes

Acoustic Differences

The raw audio data will be analyzed for change in pitch, variability of rhythm, and response time.

Time frame: Approximately 48 hours after taking antimanic medications until up to end of subject participation approximately 1 month from enrollment

Syntactical Differences

Audio data will be transcribed using voice to text software and then analyzed for syntactical elements of speech including sentence structure and grammar.

Time frame: Approximately 48 hours after taking antimanic medications until up to end of subject participation approximately 1 month from enrollment

Semantic Differences

Transcribed audio data will be analyzed for changes in verbosity, lexical diversity, and coherence on a sentence and paragraph level.

Time frame: Approximately 48 hours after taking antimanic medications until up to end of subject participation approximately 1 month from enrollment

Data from ClinicalTrials.gov

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