The Different Design of Orthokeratology

Inclusion Criteria: * The age is greater than 8 years and less than 18 years * The myopia was within -4.00D (including -4.00D), and the astigmatism was within 1.50D (including 1.50D) in both eyes. * Be able to complete 12 months of follow-up * They were able to understand the purpose of the trial, volunteered to participate, and signed informed consent by the subjects themselves or their legal guardians Exclusion Criteria: * One eye met the inclusion criteria * Patients with systemic diseases causing immunocompromised or affecting orthokeratology * There are other eye diseases that affect orthokeratology lens wearing, such as dacryocystitis, blepharitis, various inflammation, glaucoma, etc * Abnormal cornea * Previous corneal surgery or corneal trauma history * Active keratitis (e.g., corneal infection) * Patients with best corrected distance visual acuity of less than 5.0 * Patients with corneal flat curvature lower than 39.00D, or higher than 48.00D * Patients with refractive instability * Patients with overt strabismus * The corneal epithelium showed obvious fluorescent staining, which was not suitable for patients wearing orthokeratology lenses * Patients with dry eye are not suitable for orthokeratology * Patients with corneal endothelial cell density less than 2000 cells /mm2 * Patients who had worn rigid contact lenses (including orthokeratology lenses) within the previous 30 days