A randomised control trial to compare oral and vaginal misoprostol for induction of labour in term patients.The objective is to determine whether use of standardised vaginal misoprostol regimen will result in decreased cesaerean section rate among women with bishop score of lessthan or equal to 6 who require induction of labpour at term compared to oral misoprostol regimen.
The objective of study is to determine whether the use of standardised vaginal misoprostol regimen will result in decreased cesaerean section rate among women with bishop score of less than or equal to 6 who require induction of labour at term compared to oral misoprostol regimen.It is a randomised control trial conducted in department of obs and gynae unit 1 from june 2023. Total 176 patients are included in this study and they will be randomised by envelope method to recieve either oral or vaginal misoprostol in a dose of 50microgram.In both groupds dose will be repeated after 6 hours if required.Maximum 2 doses will be given.patients will be monitored for uterine contractions and fetal hearts.Vaginal examination will be done at 4hours and 8 hours following misoprostol dose or earlier if patient complains of leaking and labour pains.Membranes will be ruptured once cervical dilatation is greater than 3cm.in absence of adequate uterine contractions oxytocin infusion will be started.Fetal hearts will be monitored every 30 minutes from time of induction.Progress of labour will be assessed through partogram.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
176
oral misoprostol 50 microgram repeated after 6 hours if required
vaginal misoprostol 50 microgram repeated after 6 hours if required
Services Institute Of Medical Sciences
Lahore, Punjab Province, Pakistan
RECRUITINGvaginal birth
vaginal birth within 24 hours of admission with 2 doses of misoprostol given 6 hours apart
Time frame: vaginal birth within 24 hours of admission
cesaerean section
cesaerean section if patient doesnt go in labour despite 2 doses or fetal distress occurs
Time frame: within 24 hours
induction to delivery interval
measured from 1st dose till delivery of patient
Time frame: within 24 hours
fetal distress
fetal distress measured by non reactive CTG or meconium stained amniotic fluid
Time frame: within 24 hours
uterine hyperstimulation
more than 5 contractions in every 10 minutes
Time frame: more than 10 cotractions in every 10 minutes
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