Concentrated Platelet Rich Fibrin (C-PRF) as Adjunct to Non-surgical Periodontal Therapy

Krishnadevaraya College of Dental Sciences & Hospital48 enrolled

Overview

The current study is a prospective randomised split mouth study to evaluate the effect of concentrated Platelet Rich Fibrin as an adjunct to the scaling and root planing

Twelve healthy individuals satisfying the inclusion and exclusion criteria were recruited for the study. A detailed, thorough medical and dental history was obtained and each patient was subjected to comprehensive clinical and radiological examination. All patients were informed about the nature of the study, procedure involved, potential benefits and risks associated with procedure and written informed consent were obtained from all patients. All the patients underwent scaling and root planing. As it is split mouth study design the test site is treated with Concentrated platelet rich fibrin( C-PRF) and the contralateral site is not treated with C-PRF. Periodotal pack was placed and patient was recalled after 6 weeks for the follow up.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Periodontal Pocket

Interventions

C-PRFBIOLOGICAL

thorough scaling and root planing is performed followed by withdraw of 5ml of blood from antecubital vein of patient with consent . Following C-PRF protocol of 3000rpm for 8 min centrifugation is performed. 1ml of plasma is drawn from the test tube just above the red blood cell layer and allowed to clot and the formed clot is placed in the periodontal pocket after scaling and root planing

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patient age ranging from 18-45 years 2. Contralateral sites with probing depth 5mm-7mm associated with premolar and molar teeth with no furcation involvement 3. No systemic disease 4. Not under any medication which effect the outcome of periodontal therapy Exclusion Criteria: 1. History of any periodontal therapy within past 6 months 2. Pregnant and lactating mothers 3. Smokers smoking \>10 cigarettes per day 4. Patients with blood disorders or platelet count less than 50000 cells/ µL 5. Patients with known systemic disease 6. Non-compliant patients

Locations (1)

Krishnadevaraya college of dental sciences

Bangalore, Karnataka, India

Outcomes

Primary Outcomes

Probing pocket Depth

measured using a UNC-15 probe (university of North Carolina-15 periodontal probe- Hu-Friedy, Chicago, IL, USA)

Time frame: 6 weeks

Relative attachment level

measured by placing the acrylic stent on the selected teeth using UNC-15 probe (university of North Carolina-15 periodontal probe- Hu-Friedy, Chicago, IL, USA)

Time frame: 6 weeks

Data from ClinicalTrials.gov

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