Evaluation of HDL Subfraction Changes and HDL-Associated Enzymes in Liver Failure Patients and Healthy Donors

Akdeniz University40 enrolled

Overview

This study aimed to determine high-density lipoprotein (HDL) subfraction profile and HDL-associated enzyme changes in liver failure patients and healthy donors.

Objectives: This study aimed to determine high-density lipoprotein (HDL) subfraction profile and HDL-associated enzyme changes in liver failure patients and healthy donors. Materials and Methods: Twenty liver failure patients and twenty healthy donors are selected. Blood samples obtained from all patients prior to transplant will analyzed. HDL subfraction analysis will done by continuous disc polyacrylamide gel electrophoresis. Plasma levels of apolipoprotein A-1 (ApoA-I), cholesteryl ester transfer protein (CETP), and lecithin-cholesterol acyltransferase (LCAT) will determined by enzyme-linked immunosorbent assay.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Liver Failure

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Liver failure patients Exclusion Criteria: * patients not giving consent * Participants who had oncological and hematological diseases, coronary failure, kidney failure, malnutrition, diabetes, traumatic brain injury, or cadaveric LT and who were using psychoactive medicines or having a respiratory system or CNS diseases were excluded from the study

Locations (1)

AkdenizU

Antalya, Turkey (Türkiye)

Outcomes

Primary Outcomes

HDL Subfractions

Evaluation of HDL Subfractions in groups

Time frame: Blood will collected from all patients before surgery

Secondary Outcomes

HDL-associated enzymes

ApoA1, CETP and LCAT levels in groups

Time frame: Blood will collected from all patients before surgery

Data from ClinicalTrials.gov

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