The purpose of the proposed study is to broaden our understanding on the neural effects of High Definition Transcranial Direct Current Stimulation (HD-tDCS) so that its clinical effects can be further improved.
Normal healthy individuals will be recruited and undergo a standardized neuropsychological assessment (ANAM, MoCA, BDI-II, ToMS, and MAAS) and magnetic resonance imaging (MRI). During MRI, HD-tDCS will be applied. Four different stimulation targets will be investigated, and subjects will be randomly assigned for each target groups or sham group. After HD-tDCS/MRI session, subjects will be re-assessed with standardized neuropsychological tests.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
100
HD-tDCS will be provided for 20 minutes for each stimulation with peak intensity of 2mA.
University of Manitoba
Winnipeg, Manitoba, Canada
RECRUITINGchange of functional connectivity
Changes in seed-based connectivity originating from the targeted brain regions immediately after the brain stimulation
Time frame: 0-11 minutes after the stimulation contrasting baseline (before stimulation)
change of cerebral blood flow
Changes in Cerebral Blood Flow (estimated using pseudo continuous arterial spin labeling )
Time frame: 12-16 minutes after the stimulation contrasting baseline (before stimulation)
Toronto Mindfulness Scale (curiosity)
mindfulness scale for curiosity. min: 0, max: 30. Higher score means higher curiosity-mindfulness.
Time frame: Baseline, then within 1-2 hours from stimulation
Toronto Mindfulness Scale (decentering)
mindfulness scale for decentering. min: 0, max: 35. Higher score means higher decentering-mindfulness.
Time frame: Baseline, then within 1-2 hours from stimulation
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