The investigators will study the effect of microdoses of glucagon at the site of subcutaneous insulin injection. The investigators have unpublished data from anesthetized pigs indicating a major enhancement of insulin absorption.
People with type 1 diabetes will come fasting in the morning to the research facility on two separate days. Both days participants will have a breakfast of their own choice and their regular dose of meal insulin injected. Lyumjev will be used. Frequently collected blood sampled will be analysed for glucose, insulin and glucagon for 3.5 hours. The procedures will be exactly the same both days except that on one of the days they will be randomised to a small dose of glucagon that will be injected at exactly the same site as Lyumjev insulin is injected.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
9
A micro-dose of glucagon is added exactly at the same site as insulin is injected.
Department of Endocrinology, St. Olavs Hospital
Trondheim, Norway
Area under the glucose curve
The area under the glucose curve (change from baseline glucose level)
Time frame: From time 0 minutes to time 60 minutes
Area under glucose curve
The area under the glucose curve (change from baseline glucose level)
Time frame: Any other time span from time 0 minutes to time 180 minutes
Area under insulin curve
The area under the insulin curve
Time frame: Any time frame from time 0 minutes to time 180 minutes
Area under glucagon curve
The area under the glucagon curve
Time frame: Any time frame from time 0 minutes to time 180 minutes
Pharmacokinetics of insulin
Time to Cmax.
Time frame: Start from time 0
Pharmacokinetics of glucagon
Time to Cmax
Time frame: Start from time 0
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