The goal of this clinical trial is to compare the postprandial glucose and insulin responses after different fruit snack consumption in a healthy population.
Fruit snacks made from sweetened dried fruits is a source of polyphenols, fiber, and other nutrients. The addition of sugar could aid in the taste, texture, and shelf life of these types of products. Fruit snacks with different levels of sugar were developed to meet various consumer needs. The postprandial glucose response in a healthy population is of interest in this regard. Mulberry leaf extract has been shown the benefit of blood glucose regulation in multiple studies. This is mainly due to the function of the most predominant iminosugar, 1-deoxynojirimycin (DNJ), in the mulberry leaf extract which acts as α-glucosidase inhibitor. Fruit snacks containing mulberry leaf extract were developed and the postprandial metabolic response against a reference (white bread matched for carbohydrate) will be observed.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Enrollment
20
Fruit snacks with original level of sugar
Fruit snacks with original level of sugar and mulberry leaf extract
Fruit snacks with reduced level of sugar
Biofortis Innovation Services
Addison, Illinois, United States
Glucose maximal concentration (Cmax) 2 hours after consumption
Glucose Cmax
Time frame: 2 hour after consumption
Glucose incremental area under the curve (iAUC) from pre-product consumption to 120 min
Glucose iAUC
Time frame: 2 hours
Glucose time to maximum concentration within 2 hours after consumption
Glucose Tmax
Time frame: 2 hours
Insulin incremental area under the curve (iAUC) from pre-product consumption to 120 min
Insulin iAUC
Time frame: 2 hours
Insulin maximal concentration (Cmax) 2 hours after consumption
Insulin Cmax
Time frame: 2 hours
Insulin time to maximum concentration within 2 hours after consumption
Insulin Tmax
Time frame: 2 hours
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Fruit snacks with zero added sugar
White bread with matched carbohydrate as control