Premature infants are more likely to develop hypoxemia after birth often requiring invasive and Non-Invasive Mechanical ventilation and surfactant therapy to improve alveolar gas exchange and oxygen transport. Near-infrared spectroscopy (NIRS) has been used to detect pulmonary regional oxygen saturation (rpSO 2 ) as well as cerebral regional oxygen saturation (rcSO2 ) and evaluate the oxygenation state of the lung and brain. This is a prospective observational study to evaluate utility of rpSO2 and compare it with rcSO2 in preterm infants born between 23-32 weeks of gestation receiving noninvasive ventilation and surfactant treatment. Enrolled patients will be continuously studied with placement of NIRS monitor using cerebral sensor (INVOS™) for 6 hrs and 15 min before and after surfactant administration. Pulmonary regional oxygen saturation (rpSO2) with a sampling interval of 6 s will be followed for 6hrs.
Study Type
OBSERVATIONAL
Enrollment
50
Premature infants will be studied with brain and lung NIRS before and after surfactant administration
Los Angeles General Medical Center
Los Angeles, California, United States
rpSO2 before and after surfactant therapy
brain and lung rpSO2 will be compared before and after surfactant administration
Time frame: 6 hours
variations on rpSO2 and rcSO2 during changes in ventilation modes
Will evaluate for variations with various ventilation modes
Time frame: 6 hours
correlation between rpSO2L and SpO2/FiO2 ratio, a/APO2, and O.I
Correlation will be assessed between rpSO2 and other ratios
Time frame: 6 hours
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