The aim of the study is to compare the differences in diuretic, natriuretic and clinical response to decongestion in patients receiving different replacement fluid regimens (0.9% sodium chloride vs 5% glucose) in acute heart failure.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
50
At baseline, patients will receive a standardised dose of furosemide 1mg/kg (half of the dose administered as bolus and half as in 2h infusion). At the 6th and the 12th hour of the study patients will be reassessed and the need for additional diuretics.
Continuous 48h infusion of 0.9% sodium chloride at a fixed rate v= 83 ml/h x 24h = 2l/24h
Continuous 48h infusion of 5% Glucose at a fixed rate v= 83 ml/h x 24h = 2l/24h
Institute of Heart Diseases, Wroclaw Medical University
Wroclaw, Lower Silesian Voivodeship, Poland
Urine volume change at individual timepoints during first day of the procedure.
Comparison of urine volume between the groups at individual timepoints during the first day of the procedure.
Time frame: 24 hours
Urine volume change at individual timepoints during second day of the procedure.
Comparison of urine volume between the groups at individual timepoints during the second day of the procedure.
Time frame: 48 hours
Urine composition at individual time points.
Comparison of urine composition (urinary sodium and urinary chloride) between the groups and its change during 72h
Time frame: 72 hours
Cumulative urine output at 24 hours.
Comparison of cumulative urine output between the groups at 24 hours.
Time frame: 24 hours
Cumulative urine output at hours.
Comparison of cumulative urine output between the groups at 48 hours.
Time frame: 48 hours
Total dose of furosemide.
Comparison of the total dose of furosemide between the groups at hours.
Time frame: 48 hours
Total time on intravenous furosemide.
The total time on intravenous furosemide between hospital admission and discharge will be calculated.
Time frame: 3 months
Renin-Angiotensin-Aldosterone system activity.
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Comparison of the renin and aldosterone serum levels between the groups at the 24 hours.
Time frame: 24 hours
Renin-Angiotensin-Aldosterone system activity.
Comparison of the renin and aldosterone serum levels between the groups at the 48 hours.
Time frame: 48 hours
Heart Failure rehospitalization
Compare the need for Heart Failure rehospitalization within 30 days.
Time frame: 30 days