State Dependence of Prefrontal Transcranial Magnetic Stimulation

University of Minnesota51 enrolled

Overview

The study will examine whether the benefits of brain stimulation on mental functioning can be enhanced if an individual is actively engaging the target brain networks while receiving brain stimulation. The study includes two separate sessions and people will complete either a cognitive task or a perceptual task while receiving transcranial magnetic stimulation. The study will measure change in brain function with EEG.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Healthy

Interventions

Brain state while receiving TMSDEVICE

Brain state whilst receiving TMS - cognitive control or perceptual. Repeated measures design, so all participants receive the same procedures.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18 - 65, * healthy controls Exclusion Criteria: * Diagnosed psychiatric disorder * Potential contraindications to EEG (e.g. visible scalp abrasions, non-removable hair extensions and/or hair styling that would impede proper EEG recording) * Potential contraindication to TMS (as identified by the TMS safety screener) * Any previous adverse reaction to TMS or MRI * Diagnosed epilepsy or previously experienced a seizure * Diagnosed neurological condition, such as stroke or tinnitus * Experienced a head trauma that was diagnosed as concussion * Current use of, or recent withdrawal from, medications that can increase the risk of seizure * Currently pregnant * Any metal in the head (excluding mouth) * Any implanted medical device

Locations (1)

University of Minnesota

Minneapolis, Minnesota, United States

Outcomes

Primary Outcomes

Theta-gamma cross frequency coupling

A metric of brain function measured with EEG - the coupling of theta oscillation phase with gamma power. This will be measured immediately following the intervention (TMS stimulation).

Time frame: 0-500 ms after each TMS stimulus

Cortical excitability

TMS-evoked potentials will be measured with EEG to examine cortical excitability after TMS. This will be measured immediately following the intervention (TMS stimulation).

Time frame: 60-300 ms after each TMS stimulus

Data from ClinicalTrials.gov

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