The aim of this study is to investigate the effect of physical activity on mitochondrial function in skin fibroblasts in patients with Parkinson's disease.
A randomized double-blind clinical trial will be conducted to study the effects of physical activity on mitochondrial function in skin fibroblasts in patients with Parkinson's disease. It is an intervention study, and twenty-four patients will be needed. Once the subjects have been selected, they will be randomly assigned into three groups (eight patients in each group). The first group will perform basic physical training (BPT) based on strength and resistance, the second group will perform BPT combined with functional exercises (BPTFE) with cognitive and motor training, and the third group will not carry out any activity program, serving as control. The interventions will last 60 minutes, with a frequency of 3 times a week, during 16 weeks. The control group will receive 4 months of PA from the program that has obtained the best results,in terms of symptoms and quality of life, after the last evaluation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
24
This physical activity program will be based only on the work of basic physical training, in which specifically and mainly the strength and resistance will be worked, but also flexibility
usual clinical practice
Vall Hebron Institut de Recerca
Barcelona, Catalonia, Spain
Change in oxygen consumption rate
Oxygen uptake (VO2, mlkg-1min-1) measured by Seahorse XFe96
Time frame: Beginning of the study and after 4 months
Change in ATPmax levels
Maximal mitochondrial ATP production rates measured by Seahorse XFe96
Time frame: Beginning of the study and after 4 months
Non-motor and motor function
non-motor and motor experiences of daily living and motor complications measured by the MDS-Sponsored Revision of the UPDRS (MDS-UPDRS) questionnaire
Time frame: Beginning of the study, first visit
Sleepiness
Self-administered questionnaire with 8 questions measured by the Epworth Sleepiness Scale (ESS) questionnaire
Time frame: Beginning of the study, first visit
Mobility
clinical performance-based measure of lower extremity function, mobility and fall risk, measured by the Timed Up and Go Test (TUG) questionnaire
Time frame: Beginning of the study, first visit
Cognitive aspects
Cognitive aspects measured by the Montreal Cognitive Assessment scale (MoCA)
Time frame: Beginning of the study, first visit
Mood
Intensity of depression in clinical and normal patients measured by the Beck Depression Inventory (BDI) questionnaire
Time frame: Beginning of the study, first visit
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Non-motor and motor function
non-motor and motor experiences of daily living and motor complications measured by the MDS-Sponsored Revision of the UPDRS (MDS-UPDRS) questionnaire
Time frame: End of the study (4 Months)
Sleepiness
Self-administered questionnaire with 8 questions measured by the Epworth Sleepiness Scale (ESS) questionnaire
Time frame: End of the study (4 Months)
Mobility
clinical performance-based measure of lower extremity function, mobility and fall risk, measured by the Timed Up and Go Test (TUG) questionnaire
Time frame: End of the study (4 Months)
Cognitive aspects
Cognitive aspects measured by the Montreal Cognitive Assessment scale (MoCA)
Time frame: End of the study (4 Months)
Mood
Intensity of depression in clinical and normal patients measured by the Beck Depression Inventory (BDI) questionnaire
Time frame: End of the study (4 Months)