This study intends to analyze the characteristics between peripapillary retinal nerve fiber layer thickness and peripapillary area in high myopia with or without glaucoma
Glaucoma is the leading cause of irreversible blindness in the world. Myopia is a risk factor for glaucoma. With the rising prevalence of both myopia and glaucoma in an ageing population, the occurrence of these two ocular conditions in the same patient is likely to increase. It was estimated that there were 163 million people who have high myopia in 2000, and the population with high myopia would increase to almost one billion (9.8% of the world population) worldwide by 2050. There is often a diagnostic challenge to the clinician, since the detection of glaucomatous optic nerve damage in highly myopic eyes is difficult. Recently, the subclassification of peripapillary area could potentially be used to differentiate myopic eyes with and without glaucoma according to OCT findings. However, the characteristics of peripapillary atrophy have not been fully applied in the diagnosis of high myopia and glaucoma. In view of the above problems, the purpose of this study is to analyze the peripapillary area based on optical coherence tomography and it may be a specific marker for identifying high myopia with primary open angle glaucoma.
Study Type
OBSERVATIONAL
Enrollment
120
Image J or Spectralis OCT built-in software package was used to manually locate and measure the area and width of the temporal parapapillary atrophy.
Zhongshan Ophthalmic Center, Sun Yat-sen University
Guangzhou, Guangdong, China
Evaluation of circumpapillary retinal nerve fiber layer thickness changes within 12 months
The circle with a diameter of 3.46 mm is scanned by Spectralis OCT instrument with the optic disc as the center and the RNFL thickness was calculated by built-in software.
Time frame: 1 years
Evaluation of the area of the peripapillary area changes within 12 months
The results of Spectralis OCT instrument are exported, and used Image J or Spectralis OCT built-in software package to manually locate and measure the area of the temporal parapapillary area
Time frame: 1 year
Evaluation of the width of the peripapillary area changes within 12 months
The results of Spectralis OCT instrument are exported, and used Image J or Spectralis OCT built-in software package to manually locate and measure the width of the temporal parapapillary area
Time frame: 1 year
Demographic characteristics
Including but not limited to gender, age, duration of illness
Time frame: 1 day of enrollment
blood pressure
Demographic characteristics
Time frame: 1 day of enrollment
BMI
weight (lb) / \[height (in)\]2
Time frame: 1 day of enrollment
Best corrected visual acuity
Best corrected visual acuity after refractive error correction using the ETDRS chart
Time frame: 1 day of enrollment
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Evaluation of the intraocular pressure changes within 12 mouths
IOP is measured by goldmann tonometer.
Time frame: 1 year
Evaluation of the visual field changes within 12 mouths
Assess the degree of visual function damage
Time frame: 1 year
Axial length
axial length is measured using A-type ultrasound.
Time frame: 1 day of enrollment
Evaluation of the fundus changes within 12 months
Fundus photography uses kowa fundus camera
Time frame: 1 year
Ocular anterior segment structure
The ocular anterior segment structure uses lit-lamp biomicroscope
Time frame: 1 day of enrollment