In this study, by establishing a clinical cohort of infective endocarditis, we observed the natural prognosis and influencing factors in the process of disease development and regression; we used multi-omics technology to understand the prognostic value of its biomarkers, and provided new ideas and evidence for the pathogenesis, clinical diagnosis and treatment of IE.
Infective endocarditis is an inflammation of the inner lining of the heart valves or ventricular walls caused by direct infection of the heart by bacteria, fungi and other microorganisms via the bloodstream route. At present, the clinical diagnosis of IE is mainly based on a combination of typical symptoms, imaging and blood culture, etc. Finding more sensitive means and more accurate indicators for early detection of IE flora distribution characteristics is of great significance for the prevention and targeted treatment of IE. Therefore, in this study, by establishing a clinical cohort of infective endocarditis, we observed the natural prognosis and influencing factors in the process of disease development and regression; we used multi-omics technology to understand the prognostic value of its biomarkers, and provided new ideas and evidence for the pathogenesis, clinical diagnosis and treatment of IE.
Study Type
OBSERVATIONAL
Enrollment
2,000
Observational; No Interventions were given.
First Affiliated Hospital of Xian Jiantong University
Xi'an, Shaanxi, China
RECRUITINGChange in the incidence of MACCE
MACCE is major adverse cardio-cerebrovascular events, including myocardial infarction, stroke, vessel revascularization and all-cause death. The MACCE will be assessed from the medical records.
Time frame: 1, 3, 6 months and 1, 2, 3, 5 years after enrollment.
Incidence of adverse thrombus complications
Adverse thrombus complications including systemic embolism, infected aneurysm, splenic abscess, etc.
Time frame: 5 years after the enrollment.
Change in the incidence of infection recurrence
Diagnosis of infective endocarditis by clinical guidelines, which will be assessed from medical records.
Time frame: 1, 3, 6 months and 1, 2, 3, 5 years after enrollment.
Change in the incidence of myocardial infarction
Myocardial infarction, diagnosed by clinical doctors, will be assessed from medical records.
Time frame: 1, 3, 6 months and 1, 2, 3, 5 years after enrollment.
Change in the incidence of stroke
Stroke, diagnosed by clinical doctors, will be assessed from medical records.
Time frame: 1, 3, 6 months and 1, 2, 3, 5 years after enrollment.
Change in the incidence of vessel revascularization
Vessel revascularization, diagnosed by clinical doctors, will be assessed from medical records.
Time frame: 1, 3, 6 months and 1, 2, 3, 5 years after enrollment.
Change in the incidence of all-cause death
All-cause death, diagnosed by clinical doctors, will be assessed from medical records.
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Time frame: 1, 3, 6 months and 1, 2, 3, 5 years after enrollment.