The Incidence of Gallstones After Gastrectomy

Hepatopancreatobiliary Surgery Institute of Gansu Province531 enrolled

Overview

To provide preventive and therapeutic strategies for participants with gallstones after gastric cancer by comparing the risk of postoperative gallbladder stone formation with two different resection ranges using the Roux-en-Y reconstruction modality in radical gastric cancer surgery.

A large number of clinical studies have found that the incidence of gallstones in patients after radical gastric cancer surgery is higher than that in the normal population. However, the pathogenesis has not been clarified, and the prophylactic removal of the gallbladder in patients with gastric cancer remains controversial. A previous study found a statistically significant incidence of gallbladder stones after Billroth I versus Roux-en-Y in distal gastrectomy for gastric cancer. Therefore, the investigators plan to conduct a retrospected cohort study to collect further participants with gastric cancer who underwent total gastrectomy to answer whether different surgical resection ranges during surgery increase the incidence of gallstones this question.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

531

Conditions

Gallstone Gastric Cancer

Interventions

Distal gastrectomy and radical resectionPROCEDURE

Distal gastrectomy and Roux-en-Y anastomosis

Total gastrectomy and radical resectionPROCEDURE

Total gastrectomy and Roux-en-Y anastomosis

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with Gastric Cancer underwent Gastrectomy Exclusion Criteria: * Age less than 18 years or age greater than 75 years; * Not Roux-en-Y reconstruction; * R0 excision is not achieved; * Previous history of upper abdominal surgery, such as cholecystectomy, gastrectomy; * Preoperative gallbladder diseases, such as gallstones, gallbladder polyps, chronic cholecystitis; * Preoperative neoadjuvant chemotherapy or radiotherapy; * Previous history of malignant tumours; * Patients with mental or developmental abnormalities or women during pregnancy or breastfeeding; * Gastric perforation or bleeding leading to emergency surgery; * Palliative surgical treatment; * Incomplete case information.

Locations (2)

Hepatopancreatobiliary Surgery Institute of Gansu Province

Lanzhou, Gansu, China

Wuwei Tumor Hospital

Wuwei, Gansu, China

Outcomes

Primary Outcomes

Number of gallstone patients

Two groups of patients with gastric cancer had a follow-up for more than one year and the number of patients with gallbladder stones on B-ultrasound or Computed Tomography (CT)

Time frame: 5years

Secondary Outcomes

Number of patients with postoperative complications

The number of patients with postoperative complications such as abdominal haemorrhage, fistula, nausea, vomiting, abdominal infection and incision infection in 2 groups of gastric cancer patients

Time frame: 5years

Number of patients with bile duct stones

Two groups of patients with gastric cancer had a follow-up for more than one year. Clinical signs such as Charcot's triad and ultrasound, Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) show the number of patients with bile duct stones

Time frame: 5years

Data from ClinicalTrials.gov

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