The primary purpose of this study is to determine the effect of clarithromycin on the single-dose pharmacokinetics (PK) of brensocatib in healthy participants.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
22
Oral tablets.
Oral tablets.
USA001
Dallas, Texas, United States
Area Under the Plasma Concentration-time Curve (AUC) of Brensocatib
The effect of clarithromycin on the single dose pharmacokinetics of brensocatib will be assessed in healthy participants.
Time frame: Pre-dose and at multiple timepoints post-dose on Days 1 to 8, and Days 13 to 20
Number of Participants who Experienced at Least one Adverse Event (AE)
Determination of the safety and tolerability of a single oral dose of brensocatib when administered alone and with clarithromycin in healthy participants.
Time frame: Up to Day 27
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