Effect of Liraglutide in Obese Women With Polycystic Ovary Syndrome

Beni-Suef University183 enrolled

Overview

The aim of this study is to compare the hormonal, metabolic and clinical effects of metformin and liraglutide in infertile women with PCOs.

This prospective randomized clinical trial will be conducted at Gynecology and obstetrics department in Beni Suef University Hospital, Beni suef, Egypt. The trial will be included 150 women with Poly cystic ovary syndrome based on the Rotterdam criteria.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

183

Conditions

Polycystic Ovary

Interventions

liraglutideDRUG

glucagon-like peptide 1 receptor agonist

MetforminDRUG

biguanide antihyperglycemic

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * women aged 18-45 years * Poly cystic ovary syndrome based on the Rotterdam criteria Exclusion Criteria: 1. congenital adrenal hyperplasia, 2. poorly controlled thyroid disease 3. Taking antidiabetic drugs which can affect insulin resistance 4. chronic kidney disease 5. liver dysfunction (AST or ALT 6. Documented use of oral hormonal contraceptives and hormone-releasing implants 7. intolerance or allergy to liraglutide or metformin

Locations (1)

Beni-suef university Hospital

Banī Suwayf, Beni Suweif Governorate, Egypt

Outcomes

Primary Outcomes

Insulin Resistance (HOMA-IR)

Time frame: 6-months

Data from ClinicalTrials.gov

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