Baxdrostat Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study in a Japanese Population

Inclusion Criteria: * Male or female subjects, 18 to 55 years of age, inclusive. * Demographics as follows: 1. Japanese subjects must have been born in Japan, with both biological parents and all 4 biological grandparents of Japanese descent, have lived outside of Japan for \< 10 years, and have not significantly changed his or her diet since leaving Japan (eg, still mainly eating a "Japanese" diet), OR 2. Caucasian ancestry (Cohort 3) * Healthy status as defined by absence of evidence of any active or chronic disease following a detailed medical and surgical history, a complete physical examination including vital signs, 12-lead ECG, and laboratory assessments (hematology, chemistry, serology, and urinalysis). * A BMI between 18 - 30 kg/m2, inclusive. * Females may be of nonchildbearing or childbearing potential. Females of nonchildbearing potential are postmenopausal or surgically sterile. Females of nonchildbearing potential are exempt from the dual contraception requirement. Females of childbearing potential may be included, provided the subject agrees to continuously use dual methods of contraception from 1 month prior through 90 days after study drug administration. * Able to participate and willing to give written informed consent and to comply with the study restrictions. Exclusion Criteria: 1. Any clinically relevant history or the presence of respiratory, renal, hepatic, gastrointestinal, hematological, lymphatic, neurological, cardiovascular, psychiatric, musculoskeletal, genitourinary, immunological, dermatological, allergic, ophthalmological disease or connective tissue disease, cancer or cirrhosis. 2. A history of clinically significant drug hypersensitivity. 3. Subjects with clinically significant symptoms of an infectious illness (bacterial, viral, or parasitic) within 5 days of the first dose or a history of recurrent infections. 4. History of alcohol abuse, illicit drug use, physical dependence to any opioid, or any history of drug abuse or addiction (including soft drugs like cannabis products) within 6 months of screening. 5. Nicotine users unable or unwilling to restrict nicotine usage to the equivalent of 5 cigarettes daily during the study and to not smoke during the in-clinic stays. (Nicotine-containing products include cigarettes, chewing tobacco, snuff, nicotine patches, electronic cigarettes, vaping devices, etc.) 6. Positive result for HIV-1 or HIV-2, hepatitis C virus (HCV), or HBsAg at screening. 7. Confirmed (based on the average of ≥ 3 blood pressure measurements) sustained systolic blood pressure \> 140 or \< 90 mmHg, and diastolic blood pressure \> 90 or \< 45 mmHg, and pulse rate \> 100 or \< 40 bpm. 8. Personal or family history of congenital long QT syndrome or QTcF values \> 450 msec in males or \> 470 msec in females. 9. Screening or baseline ECGs with QRS and/or T-wave judged by the Investigator to be unfavorable for a consistently accurate QT measurement (ie, neuromuscular artifact that cannot be readily eliminated, arrhythmias, indistinct QRS onset, low amplitude T-wave, merged T- and U-waves, prominent U-waves, etc.) 10. Screening or baseline ECG with clinically significant abnormalities such as atrial fibrillation, atrial flutter, complete bundle branch block, Wolf-Parkinson-White Syndrome, or cardiac pacemaker, as judged by the Investigator. 11. Clinically significant abnormalities in laboratory test results (including hepatic and renal panels, complete blood count, chemistry panel, and urinalysis) at screening or prior to dosing. The Medical Monitor may be consulted to discuss questionable abnormalities. Laboratory values that are not clinically significant, in the Investigator's opinion, may be allowable. In addition, subjects with the following will be excluded from the study (regardless of significance): * red blood cell count \< 0.75 x lower limit of normal (LLN) * white blood cell count \< 0.75 x LLN * hemoglobin \< 0.75 x LLN * aspartate transaminase \> 1.25 x upper limit of normal (ULN) * alanine aminotransferase \> 1.25 x ULN * potassium \> ULN * sodium \< LLN In case of questionable results, tests performed during screening or Day -2 may be repeated before dosing to confirm eligibility. 12. Subjects with estimated glomerular filtration rate \< 60 mL/min (according to the Modification of Diet in Renal Disease formula). 13. Subjects with clinically significant orthostatic hypotension (defined as a decrease in systolic blood pressure of ≥ 20 mmHg or a decrease in diastolic blood pressure of ≥ 10 mmHg at 2 minutes of standing). 14. Donation of blood \> 450 mL within 3 months prior to screening or plasma within 14 days of dose administration. 15. Concomitant disease or condition that could interfere with, or for which the treatment thereof, might interfere with, the conduct of the study, or that would, in the opinion of the Investigator, pose an unacceptable risk to the subject in this study. 16. Known intolerance to cosyntropin test product. 17. Use of prescription, over-the-counter, or herbal medications within 14 days prior to dose administration. 18. Participation in an investigational drug or device study within 30 days or 5 half-lives, whichever is longer, prior to dosing. 19. Corticosteroid use (systemic or extensive topical use) within 3 months prior to dosing. 20. Has received a vaccination within 14 days prior to administration of the study drug. 21. Males must agree to not donate sperm from screening through 90 days after study drug administration has been completed. 22. Strenuous activity (as assessed by the Investigator) within 48 hours prior to clinical site admission. 23. Consumption of alcohol or caffeine-containing food or beverages within 3 days prior to admission to the clinical site. 24. Involved in the planning or conduct of this study. 25. Unwilling or unlikely to comply with the requirements of the study.