Localized Analysis of Normalized Distance From Scalp to Cortex and Personalized Evaluation (LANDSCAPE)

N/AEnrolling By InvitationNCT05967390

Chinese University of Hong Kong488 enrolled

Overview

Scalp to cortex distance (SCD), as a key technological parameter of brain stimulation, has been highlighted in the guidelines of non-invasive brain stimulation. However, in the context of age-related brain changes, the region-specific SCD and its impact on stimulation-induced electric field in different types of neurodegenerative diseases remain unclear.

Objective: This study aimed to investigate the region-specific SCD and its relationship with morphometric features and cognitive function in age- and disease-specific populations. Methods: The SCD and cortical thickness (CT) of left primary motor cortex (M1) and dorsolateral prefrontal cortex (DLPFC) were measured in cognitively normal adults and dementia patients. CT-adjusted SCD was used to control the influence of CT on SCD. Head model was developed to simulate the impact of SCD on the electric field induced by transcranial electrical stimulation.

Study Type

OBSERVATIONAL

Enrollment

488

Conditions

Aging Dementia Alzheimers Parkinson Disease Dementia Frontotemporal Depression in Old Age

Eligibility

Sex: ALLMin age: 60 YearsMax age: 95 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Right-handed as assessed by the Edinburgh Inventory * Able to attend TMS interventions * Consent * Independent in daily life activities Exclusion Criteria: * Uncorrected visual or auditive deficits not allowing the realization of the test * Evolutive disease (such as cancer) * Neurological or psychiatric antecedent * Counter-indication to MRI

Outcomes

Primary Outcomes

Scalp-to-cortex distance will be measured using geometric brain model

Scalp-to-cortex distance (SCD), as a geometric feature, will measured in the Brainsight TMS neuronavigation system.

Time frame: Baseline