Correlation Between Serum Uric Acid and Pulmonary Hypertension in Obstructive Sleep Apnea Syndrome

Alexandria University100 enrolled

Overview

This study aimed to correlate serum uric acid levels and PAH in OSAHS patients.

Obstructive sleep apnea-hypopnea syndrome is the most common form of SRBDs. Recurrent hypoxia, that accompanies OSAHS increases the degradation of ATP, which in turn increase uric acid concentration that can be used as a biomarker of tissue hypoxia in OSAHS. There is still debate about whether OSAHS is an independent contributor to pulmonary arterial hypertension. AIM OF THE WORK This study aimed to correlate serum uric acid levels and PAH in OSAHS patients. Methods We enrolled 100 patients diagnosed with OSAHS using polysomnography. Patients were divided into three severity groups: mild OSA (5 ≤ AHI \< 15), moderate OSA (15 ≤ AHI \< 30), and severe (30 ≤ AHI \< 60). Serum uric acid was measured the morning after polysomnography. All patients underwent standard echocardiograms, and Pulmonary artery systolic pressure calculation was done.

Study Type

INTERVENTIONAL

Allocation

Purpose

SCREENING

Masking

NONE

Enrollment

100

Conditions

Obstructive Sleep Apnea

Interventions

polysomnographyDIAGNOSTIC_TEST

polysomnography and serum uric acid measurement

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of OSAHS by overnight polysomnography (AHI ≥ 5/ hr) * ≥18 years old. Exclusion Criteria: * Other sleep disorders as narcolepsy or hypersomnia were excluded as well as Patients with neuropsychiatric disorders. * Hemodynamically unstable patients * Patients with other chronic respiratory or cardiac diseases * Patients with other known causes of pulmonary hypertension * Patients with any disease or on medication that could alter excretion or urinary metabolism of uric acid such as Excessive uric acid production

Locations (1)

Rania Ahmad Sweed

Alexandria, Egypt

Outcomes

Primary Outcomes

This study aimed to correlate serum uric acid levels and Pulmonary Arterial Hypertension in Obstructive Sleep Apnea Hypopnea Syndrome patients.

Time frame: one Year

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.