Participants will perform Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Clinical Dementia Rating (CDR), Alzheimer's disease assessment scale-cognitive section (ADAS-Cog), Hamilton Anxiety Scale (HAMA) and Hamilton Depression Rating Scale (HAMD) evaluation. The patients will be randomly divided into two groups, treated with lacosamide and levetiracetam respectively, and maintained for 6 months. Researchers will compare the lacosamide group with the levetiracetam group to see if the improvement of cognitive function in the two groups.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
140
Subjects who were randomly divided into group A took lacosamide for 6 months during treatment (initial dose was 50mg bid, maintained for one week and then increased to 100mg bid and maintained at this dose)
Subjects randomly divided into group B took levetiracetam for 6 months during treatment (initial dose was 250mg bid, maintained for one week and then increased to 500mg bid and maintained at this dose).
Xiangya Hospital of Central South University
Changsha, Hunan, China
RECRUITINGMini-Mental State Examination (MMSE)
The minimum value is 0, the maximum value is 30, the higher scores means a better cognition.
Time frame: At the time of enrollment
Mini-Mental State Examination (MMSE)
The minimum value is 0, the maximum value is 30, the higher scores means a better cognition.
Time frame: 1 month after enrollment
Mini-Mental State Examination (MMSE)
The minimum value is 0, the maximum value is 30, the higher scores means a better cognition.
Time frame: 3 months after enrollment
Mini-Mental State Examination (MMSE)
The minimum value is 0, the maximum value is 30, the higher scores means a better cognition.
Time frame: 6 months after enrollment
Montreal Cognitive Assessment (MoCA)
The minimum value is 0, the maximum value is 30, the higher score means a better cognition.
Time frame: At the time of enrollment
Montreal Cognitive Assessment (MoCA)
The minimum value is 0, the maximum value is 30, the higher score means a better cognition.
Time frame: 1 month after enrollment
Montreal Cognitive Assessment (MoCA)
The minimum value is 0, the maximum value is 30, the higher score means a better cognition.
Time frame: 3 months after enrollment
Montreal Cognitive Assessment (MoCA)
The minimum value is 0, the maximum value is 30, the higher score means a better cognition.
Time frame: 6 months after enrollment
Clinical Dementia Rating (CDR)
The minimum value is 0, the maximum value is 3, the higher scores means a great likelihood of dementia.
Time frame: At the time of enrollment
Clinical Dementia Rating (CDR)
The minimum value is 0, the maximum value is 3, the higher scores means a great likelihood of dementia.
Time frame: 1 month after enrollment
Clinical Dementia Rating (CDR)
The minimum value is 0, the maximum value is 3, the higher scores means a great likelihood of dementia.
Time frame: 3 months after enrollment
Clinical Dementia Rating (CDR)
The minimum value is 0, the maximum value is 3, the higher scores means a great likelihood of dementia.
Time frame: 6 months after enrollment
Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) scale
The minimum value is 0, the maximum value is 75, the higher scores means a great likelihood of dementia
Time frame: At the time of enrollment
Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) scale
The minimum value is 0, the maximum value is 75, the higher scores means a great likelihood of dementia
Time frame: 1 month after enrollment
Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) scale
The minimum value is 0, the maximum value is 75, the higher scores means a great likelihood of dementia
Time frame: 3 months after enrollment
Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) scale
The minimum value is 0, the maximum value is 75, the higher scores means a great likelihood of dementia
Time frame: 6 months after enrollment
Hamilton Anxiety Scale (HAMA)
The minimum value is 0, the maximum value is 56, the higher scores means a great likelihood of anxiety
Time frame: At the time of enrollment
Hamilton Anxiety Scale (HAMA)
The minimum value is 0, the maximum value is 56, the higher scores means a great likelihood of anxiety
Time frame: 1 month after enrollment
Hamilton Anxiety Scale (HAMA)
The minimum value is 0, the maximum value is 56, the higher scores means a great likelihood of anxiety
Time frame: 3 months after enrollment
Hamilton Anxiety Scale (HAMA)
The minimum value is 0, the maximum value is 56, the higher scores means a great likelihood of anxiety
Time frame: 6 months after enrollment
Hamilton Depression Scale (HAMD)
The minimum value is 0, the maximum value is 77, the higher scores means a great likelihood of depression
Time frame: At the time of enrollment
Hamilton Depression Scale (HAMD)
The minimum value is 0, the maximum value is 77, the higher scores means a great likelihood of depression
Time frame: 1 month after enrollment
Hamilton Depression Scale (HAMD)
The minimum value is 0, the maximum value is 77, the higher scores means a great likelihood of depression
Time frame: 3 months after enrollment
Hamilton Depression Scale (HAMD)
The minimum value is 0, the maximum value is 77, the higher scores means a great likelihood of depression
Time frame: 6 months after enrollment
Seizure frequency
Record seizure frequency
Time frame: At the time of enrollment
Seizure frequency
Record seizure frequency
Time frame: 1 month after enrollment
Seizure frequency
Record seizure frequency
Time frame: 3 months after enrollment
Seizure frequency
Record seizure frequency
Time frame: 6 months after enrollment
EEG discharge
Record interictal epileptic discharge under the 24-hour VEEG
Time frame: At the time of enrollment
EEG discharge
Record interictal epileptic discharge under the 24-hour VEEG
Time frame: 1 month after enrollment
EEG discharge
Record interictal epileptic discharge under the 24-hour VEEG
Time frame: 3 months after enrollment
EEG discharge
Record interictal epileptic discharge under the 24-hour VEEG
Time frame: 6 months after enrollment
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