Effectiveness of Hydrolyzed Collagen Peptide Injection for the Treatment of Collateral Ligament Pain

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Overview

Conducted by Binh Luu Thi, Lan Tran Thi, and Minh Hang Hoang Thi at Thai Nguyen National Hospital, the study investigates a new approach to treating persistent collateral ligament pain, common among athletes. The research examines the therapeutic use of hydrolyzed collagen peptide injections, a treatment that addresses pain and inflammation in ways previous methods have not. The study involves a randomized controlled trial with 62 patients, all diagnosed with inflammation in the collateral ligament site. The patients are split into two groups: one receiving collagen injections alongside oral painkillers and the other receiving depo-medrol injections with oral painkillers.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Collateral Ligament Injury of Stifle Joint

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age above 18 years, * lateral knee pain with a duration of 3 months or longer, * ultrasound evidence of inflammation of the femoral condyle attachment point, * agreement to participate in the study Exclusion Criteria: * trauma, * infection, * dermatitis at the site of the inflammation, * damage to surrounding knee structures, * history of chronic inflammatory arthritis (such as gout or rheumatoid arthritis), * local corticosteroid injection within 3 months before participating in the study.

Outcomes

Primary Outcomes

WOMAC

Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) assessing functionality from 0 to 96 for the total WOMAC where 0 represents the best health status and 96 the worst possible status.

Time frame: 6 months

Secondary Outcomes

VAS (Visual Analogue Pain)

Visual Analogue Pain assessing pain from 0 (no pain) to 10 (unbearable pain)

Time frame: Baseline, 3 months, 6 months

Ultrasound

Ultrasound evaluation for hypoechoic (signal reduction), normal, and hyperechoic (signal amplification) ligaments. Hypoechoic signal suggests damage or degeneration of the ligament; normal signal suggests healthy ligament tissue; hyperechoic signal suggests calcification, scar, or inflammation.

Time frame: Baseline, 3 months, 6 months

Likert

Likert scale for patients' satisfaction from 1 (no statisfaction) to 5 (maximum satisfaction)

Time frame: Baseline, 6 months