Comparing Ciprofol and Propofol for Sedation in Hypotensive ICU Patients: a Single Center Prospective Cohort Study

Nanfang Hospital, Southern Medical University456 enrolled

Overview

This study was a single-center, prospective, 2-year observational cohort study. The study subjects were ICU patients requiring vasopressor drugs and requiring sedation. According to the use of ciprofol or propofol in the treatment plan (determined by the doctor in charge according to the condition of the subjects), they were divided into groups: ciprofol group and propofol group. A total of 456 subjects were planned to be enrolled, including 304 subjects in the cyclopofol group and 152 subjects in the propofol group. The data of this study were obtained by extracting the routine clinical diagnosis and treatment records of the enrolled subjects.

Study Type

OBSERVATIONAL

Enrollment

456

Conditions

Ciprofol Propofol Sedation Low Blood Pressure Norepinephrine

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥ 18; * It needs to be treated with vasopressors to maintain mean arterial pressure ≥65 mmHg; * Sedative medication required for comfort, safety, and to facilitate life support measures; * Obtain the informed consent of the human subjects or their legal representatives. Exclusion Criteria: * Pregnant patient; * Patients with proven acute severe intracranial or spinal neurological disease due to vascular, intracranial dilatation, or injury; * History of allergy to cyclopofol, propofol, eggs, or soy products; * History of long-term use of benzodiazepines or opioids; * Sedative drugs other than propofol or cyclopofol were used at enrollment, or propofol and cyclopofol were used alternately within 24 hours; * The researchers judged that they are not suitable to participate in this study.

Outcomes

Primary Outcomes

The proportion of patients meeting the RASS sedation

Professionally trained researchers perform RASS scores on patients at specific time points

Time frame: within 24 hours

Secondary Outcomes

Dosage of propofol or ciprofol during sedation (total dose/time of use)

Responsible researchers consult the patient's medical record after completing treatment to obtain the dosage and duration of medication

Time frame: up to 24 hours

Dosage of norepinephrine during sedation (total dose/time of use)

Responsible researchers consult the patient's medical record after completing treatment to obtain the dosage and duration of medication

Time frame: up to 24 hours

Duration of mechanical ventilation

Responsible researchers obtain information by viewing electronic medical records

Time frame: From endotracheal intubation to withdrawal from mechanical ventilation,up to 28 days

Incidence of adverse events

The occurrence of adverse events during the hospital period will be recorded in the medical record by the clinician or nurse, and the researcher will obtain the occurrence of adverse events (event type, time, treatment, results, etc.) through the medical record

Time frame: up to 3 days

length of ICU stay

Researchers obtain it through the hospital electronic system

Time frame: up to 28 days

The mortality rate

Researchers obtain it through the hospital electronic system.

Time frame: up to 28 days

Central Contacts

Zengzhu He, master

CONTACT

+8615766358044 hzengzhu@163.com

Hongbin Hu, doctor