Effect of Tadalafil, Sildenafil and Pentoxyfylline on Frozen Embryo Transfer Outcomes

Beni-Suef University200 enrolled

Overview

The aim of this study is to investigate the Effect of different vasodilators as Tadalafil, Sildenafil and pentoxyfylline in In vitro Fertilization. In addition, the thickness of endometrium and pregnancies rates of these women will also be examined. All adverse effects of all drugs will be estimated

A prospective randomized clinical study will be conducted in the IVF clinic of the gynecology department of Beni Suef University Hospital, Beni-Suef, Egypt. The study will These patients will be randomized into four groups. The participants will take drugs starting from the end of menstruation cycle till endometrium reach optimal and then will start progesterone 800 mg daily.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

200

Conditions

IVF

Interventions

tadalafilDRUG

tadalafil 10 mg one tablet daily

SildenafilDRUG

sildenafil 20 mg two tablets daily

pentoxifyllineDRUG

pentoxifylline 400 mg two tabs daily

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * women having thawed embryos Exclusion Criteria: * hypotension * cardiovascular, hepatic, and renal diseases; * uncontrolled diabetes mellitus; * ovarian cysts; * hyperprolactinemia; * abnormal thyroid functions; * uterine fibroids; * patients taking nitrates; * endometriosis and adenomyosis

Locations (1)

Beni-suef university Hospital

Banī Suwayf, Beni Suweif Governorate, Egypt

Outcomes

Primary Outcomes

endometrial thickness

measured by transvaginal ultrasound

Time frame: within 16 day of menstruation

Secondary Outcomes

pregnancy rate

number of cases positive serum pregnancy test

Time frame: 1 month

Data from ClinicalTrials.gov

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