The purpose of this study is to determine if abuse liability indices will be impacted by varying flavors and e-cigarette (ECIG) nicotine delivery capability (i.e., nicotine flux) among current combustible cigarette users. The investigators will compare abuse liability indices between three FDA-authorized ECIG products that vary in nicotine flux (but are all tobacco flavor) and own brand cigarettes. The investigators will also test the influence of ECIG flavor availability (tobacco vs. menthol) within three ECIG product classes.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
40
Subjective measures 1 is followed by product sampling that includes 5 self-directed ECIG/own brand cigarette puffs over 10 minutes. After sampling is complete participants complete subjective measures 2. Ten minutes after their sampling has been completed, they complete subjective measures 3 and the behavioral economic task(s). These activities are preceded and followed by cardiovascular response assessment.
Center for the Study of Tobacco Products
Richmond, Virginia, United States
Breakpoint of Drug Purchase Task (DPT)
The DPTs will yield measures of willingness to pay and measures of price sensitivity for session-specific tobacco products. Choices made during this task are not reinforced during the session.
Time frame: Each DPT will be completed twice per study session, about 55 minutes into the session and again at 120 minutes into the session
Elasticity of Drug Purchase Task (DPT)
The DPTs will yield measures of willingness to pay and measures of price sensitivity for session-specific tobacco products. Choices made during this task are not reinforced during the session.
Time frame: Each DPT will be completed twice per study session, about 55 minutes into the session and again at 120 minutes into the session
Omax of Drug Purchase Task (DPT)
The DPTs will yield measures of willingness to pay and measures of price sensitivity for session-specific tobacco products. Choices made during this task are not reinforced during the session.
Time frame: A DPT will be Each DPT will be completed twice per study session, about 55 minutes into the session and again at 120 minutes into the session once for each arm.
Pmax of Drug Purchase Task (DPT)
The DPTs will yield measures of willingness to pay and measures of price sensitivity for session-specific tobacco products. Choices made during this task are not reinforced during the session.
Time frame: Each DPT will be completed twice per study session, about 55 minutes into the session and again at 120 minutes into the session
Intensity of Drug Purchase Task (DPT)
The DPTs will yield measures of willingness to pay and measures of price sensitivity for session-specific tobacco products. Choices made during this task are not reinforced during the session.
Time frame: Each DPT will be completed twice per study session, about 55 minutes into the session and again at 120 minutes into the session
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Cross-price elasticity of the Cross Product-DPT
The Cross Product (CP)-DPTs assess cross-product purchasing behaviors between various tobacco products offered at a fixed amount and own brand cigarettes offered at varying prices.
Time frame: Each CP-DPT will be completed twice per study session, about 55 minutes into the session and again at 120 minutes into the session