The Atherogenic Index of Plasma（AIP） in Patients With Atrial Fibrillation

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University5,000 enrolled

Overview

The goal of this observational study is to learn about The Atherogenic Index of Plasma(AIP) in patients with atrial fibrillation(AF). The main questions it aims to answer are: (1)To investigate the correlation between AIP and the occurrence rate of AF. (2) To investigate the correlation between AIP and the occurrence rate of cardiovascular outcome events (MACE events, heart failure, embolism events) in patients with AF. Patients's clinical data including medical history, laboratory tests, and imageological examination will be collected and further analysed.

Baseline demographic data: age, gender, height, weight, systolic blood pressure, diastolic blood pressure, smoking habit, drinking habit, physical activity, fasting blood glucose, medication use (statins, ACEI/ARB, anticoagulant related drugs), basic medical history (hypertension, diabetes mellitus, coronary heart disease).

Study Type

OBSERVATIONAL

Enrollment

5,000

Conditions

Atrium; Fibrillation Lipid Metabolism Disorders Cardiovascular Diseases Event, Cardiac

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Atrial fibrillation was detected by electrocardiogram or 24-hour holter or portable electrocardiogram monitor; 2. age ≥18 years old; 3. "low-intermediate" risk group of AF cardioembolic stroke: male patients with CHA2DS2-VASc score 0-1 or female patients with CHA2DS2-VASc score 1-2 Exclusion Criteria: 1. patients with rheumatic heart disease, congenital heart disease, cardiomyopathy, hematological diseases, severe hepatic and renal insufficiency and connective tissue diseases; 2. Echocardiography showed valvular heart disease; 3. patients with transient atrial fibrillation secondary to reversible causes: hyperthyroidism, acute pulmonary embolism, recent surgery, acute myocardial infarction, etc. 4. severe carotid artery stenosis and intracranial artery stenosis; 5. AF patients with recent major surgery. 6. patients with serious lack of clinical data.

Outcomes

Primary Outcomes

atrial fibrillation (AF)

AF diagnoses were ascertained by 3 different sources in our study: ECGs performed at study visits, hospital discharge codes, and death certificates. All ECGs automatically coded as AF were visually checked by a trained cardiologist to confirm AF diagnosis.

Time frame: 10 years

Secondary Outcomes

major adverse cardiovascular events (MACEs)

Follow up main adverse cardiovascular and cerebrovascular events such as death, myocardial infarction, stroke, and repeated revascularization.

Time frame: 10 years

heart failure

Patients who required intravenous medications for heart failure after admission (including diuretics, vasodilators, or inotropic agents) or a significant increase in the dose of oral diuretics (i.e., an increase in furosemide of ≥40mg or equivalent or the addition of a thiazide to a loop diuretic) were considered to have heart failure readmission. Pulmonary rales and/or the third heart sound, chest X-ray, dyspnea, peripheral edema, and NYHA grade were evaluated to further confirm the occurrence of heart failure.

Time frame: 10 years