The Effect of Short-term L-citrulline Supplementation on Blood Pressure and Arterial Stiffness

European University Cyprus12 enrolled

Overview

The goal of this clinical trial is to examine the effect of short-term L-Citrulline on central and peripheral blood pressure in healthy older adults. The main questions it aims to answer are: * Does L-citrulline favorably affect blood pressure at rest and during exercise? * Does L-citrulline favorably affect arterial stiffness? * Does L-citrulline favorably affect muscle oxygenation at rest and during exercise? Participants will be asked to consume L-citrulline and a placebo for six days and participate in the evaluation of their blood pressure, arterial stiffness, and muscle oxygenation before and after each intervention. Researchers will compare L-citrulline and placebo groups to examine whether L-citrulline supplementation affects the above health parameters.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Blood Pressure

Interventions

Eligibility

Sex: MALEMin age: 55 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * subject provides written informed consent. * normal health profile. Exclusion Criteria: * history of musculoskeletal injury in the legs during the previous six months. * smoker. * consumption of any medication the last three months. * consumption of any nutritional supplement the last three months.

Outcomes

Primary Outcomes

Change in aortic and brachial systolic blood pressure (rest)

Time frame: Change from baseline aortic and brachial systolic blood pressure at 7 days.

Change in aortic and brachial systolic blood pressure

Time frame: Change from baseline aortic and brachial systolic blood pressure at the second minute of exercise.

Change in carotid-femoral pulse wave velocity (cfPWV) (rest)

Time frame: Change from baseline aortic and brachial systolic blood pressure at 7 days.

Secondary Outcomes

Change in pulse pressure (rest)

Time frame: Change from baseline pulse pressure at 7 days.

Change in heart rate (rest)

Time frame: Change from baseline heart rate at 7 days.

Change in augmented pressure (rest)

Time frame: Change from baseline augmented pressure at 7 days.

Change in augmentation index (rest)

Time frame: Change from baseline augmentation index at 7 days.

Change in forward and backward wave pressure (rest)

Time frame: Change from baseline forward and backward wave pressure at 7 days.

Change in muscle oxyhemoglobin (rest)

Time frame: Change from baseline oxyhemoglobin at 7 days.

Change in pulse pressure (exercise)

Time frame: Change from baseline pulse pressure at the second minute of exercise.

Change in heart rate (exercise)

Time frame: Change from baseline heart rate at the second minute of exercise.

Change in augmented pressure (exercise)

Time frame: Change from baseline augmented pressure at the second minute of exercise.

Change in augmentation index (exercise)

The ideal augmentation index is between 20 and 80. Values above 80 are considered high, and above 121 indicate high arterial stiffness.

Time frame: Change from baseline augmentation index at the second minute of exercise.

Change in forward and backward wave pressure (exercise)

Time frame: Change from baseline forward and backward wave pressure at the second minute of exercise.

Change in muscle deoxyhemoglobin (exercise)

Time frame: Change from baseline muscle deoxyhemoglobin at the second minute of exercise.

Change in muscle deoxyhemoglobin (rest)

Time frame: Change from baseline muscle deoxyhemoglobin at 7 days.

Change in muscle oxyhemoglobin (exercise)

Time frame: Change from baseline muscle oxyhemoglobin at the second minute of exercise.