Evaluation of the Efficacy of Preoperative Ketamine Nebulization on Postoperative Sore Throat Due to Tracheal Intubation for Adult Patients Under General Anesthesia, A Prospective Randomized Controlled Study

Sohag University80 enrolled

Overview

Sore throat includes specific symptoms such as dysphagia, dysphonia, hoarseness, continuous throat pain, and pharyngeal dryness. Patients rated postoperative sore throat (POST) as the eighth most undesirable outcome in the postoperative period POST has a reported incidence of up to 62% following general anesthesia (GA). The incidence of POST is more common in GA with tracheal intubation than in GA with the supraglottic airway Ketamine is an N-methyl-D-aspartate (NMDA) receptor antagonist and has been used as a gargle for reducing the incidence and severity of POST due to its anti-nociceptive and anti-inflammatory effects

Study Type

OBSERVATIONAL

Enrollment

Conditions

Post Operative Sore Throat

Interventions

KetamineDRUG

description

Eligibility

Sex: ALLMin age: 16 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age 16-60 years. 2. Of both sex. 3. American Society of Anesthesiologists Physical Status (ASA PS) I-II. 4. Undergoing general anesthesia with endotracheal intubation with surgery duration less than two hours. Exclusion Criteria: * a- History of chronic obstructive History of sore throat or upper respiratory tract infection. b- Intraoral and intrapharyngeal surgery. c- airway disease or Asthma. d- Mallampati grade more than II. e- Known allergic to study drug. f- More than one attempt is required for intubation. g- Hypertensive patients. h- Epileptic patients. i- cerebral palsy or any neurological disorders. j- Psychiatry patients. k- Cardiac patients. l- Perioperative use of anti-inflammatory drugs (Non-steroidal anti-inflammatory drug or steroids).

Outcomes

Primary Outcomes

the incidence and severity of POST

the study is to measure the incidence and severity of POST at immediate recovery (0 h), 2, 4, 6, 8, 12 and 24 h post-operatively. in adult patients undergoing surgery of a duration less than 2h.

Time frame: at immediate recovery (0 h), 2, 4, 6, 8, 12 and 24 h post-operatively.

Secondary Outcomes

evaluation of side effects including nausea, vomiting, cough, and dry mouth in both groups.

Time frame: at immediate recovery (0 h), 2, 4, 6, 8, 12 and 24 h post-operatively.

Central Contacts

Doaa A Abdellatif, resident

CONTACT

01119950167 doaaahmed@med.sohag.edu.eg

fawzy A Badawy, assistant professor

CONTACT

01004862474