The goal of this clinical trial is to investigate The effects of an anti-inflammatory diet with or without curcumin supplementation on anthropometric measurements, concentrations of thyroid hormones, anti-TPO, and systemic inflammation in plasma and NFK-B in peripheral blood mononuclear cells in patients with Hashimoto. The main questions it aims to answer are: 1. Does prescribing an anti-inflammatory diet with or without curcumin supplementation significantly affect the changes in anthropometric measurements (weight, body mass index, BMI, waist circumference, waist-to-hip ratio) in patients with Hashimoto's disease? 2. Does prescribing an anti-inflammatory diet with or without curcumin supplementation significantly affect the changes in the serum concentration of thyroid hormones (T3, T4, TSH) in patients with Hashimoto's disease? 3. Does prescribing an anti-inflammatory diet with or without curcumin supplementation significantly affect the change of Anti-TPO concentration in patients with Hashimoto's disease? 4. Does prescribing an anti-inflammatory diet with or without curcumin supplementation significantly affect the changes in systemic inflammation indicators (hs-CRP, IL-6) in plasma and NF-κB in peripheral blood mononuclear cells in patients with Hashimoto's disease?
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Enrollment
60
Daily consumption of three 500 mg curcumin capsules with breakfast, lunch, and dinner
The anti-inflammatory diet will be personalized based on each person's calorie intake in five meals. Achieving the goals of an anti-inflammatory diet by consuming only one type of food or following its principles in one meal is impossible and must be implemented consistently and regularly in a meal plan.
Golbon Sohrab
Tehran, National Nutrition and Food Technology Research Institute, Iran
IL6
Interleukin 6
Time frame: 3 month
hs-Crp
high-sensitivity C-reactive protein
Time frame: 3 month
NF-KB
Nuclear factor kappa-light-chain-enhancer of activated B cells
Time frame: 3 month
Anti-tpo
antithyroperoxidase
Time frame: 3 month
T4
Thyroxine
Time frame: 3 month
T3
Triiodothyronine
Time frame: 3 month
TSH
Thyroid-stimulating hormone
Time frame: 3 month
waist circumference
waist circumference in Centimeter
Time frame: 3 month
hip circumference
hip circumference in Centimeter
Time frame: 3 month
waist to hip ratio
an Anthropometric index
Time frame: 3 month
BMI
Body Mass Index - Anthropometric index
Time frame: 3 month
Total Cholestrol
serum lipid profile
Time frame: 3 month
TG
Triglyceride - serum lipid profile
Time frame: 3 month
Hb
hemoglobin - Blood test
Time frame: 3 month
hematocrit
Blood test
Time frame: 3 month
LDL
low-density lipoprotein
Time frame: 3 month
HDL
high-density lipoprotein
Time frame: 3 month
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.