By 2030 the number of patients with Parkinson's Disease (PD) would increase by 56% affecting 1 out of 120 people older than 45 years-old. It is known that 10-15 years before the onset motor symptoms such as tremor, rigidity and akinesia, patients often experience a specific sleep trouble called REM sleep behaviour disorder (RBD). Follow-up of those subjects showed there was a conversion rate to PD and related disorders (called synucleinopathies) over 80%. The pathophysiology of RBD is poorly understood. The development of cutting-edge technologies such as 7 Tesla MRI and the optimisation of image processing methods made it possible to non-invasively explore in vivo small brain structures involved in sleep and movement disorders. The investigators hypothesize that brain and brainstem microstructure, composition, sodium homeostasis and connectivity may change in 15 isolated RBD (iRBD) subjects compared with 15 healthy controls and that these changes may be correlated with clinical scores. This study would help fill the gap in early diagnosis of synucleinopathies, by contributing to better targeting patients who could be included in therapeutic trials with a neuroprotective effect. Besides, the exploration of original pathophysiological pathways such as sodium homeostatis could provide the necessary arguments for the development of new target therapeutics.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
31
Subjects will have a 7T MRI and questionnaires on the only day of clinical study.
Assistance - Publique Hôpitaux de Marseille
Marseille, France
3D cartography the rate of difference of atrophy between the idiopathic REM Sleep Behaviour Disorder (iRBD) and control subjects
Voxel based morphometry evaluated with Matlab and SnPM
Time frame: Time of the Inclusion
3D cartography difference of neuromelanin between the iRBD and control subjects with T1 sequence
Neuromelanin contrast ratio
Time frame: Time of the Inclusion
3D cartography difference of neuromelanin between the iRBD and control subjects with Magnetization transfert sequence
Magnetization transfert contrast ratio
Time frame: Time of the Inclusion
3D cartography the rate of difference of Quantitative Susceptibility Mapping between the iRBD and control subjects
Iron load evaluation in ppb
Time frame: Time of the Inclusion
3D cartography difference of Mean diffusivity between the iRBD and control subjects
Mean diffusivity in mm2/s
Time frame: Time of the Inclusion
3D cartography difference of Fractional anisotropy between the iRBD and control subjects
Fractional anisotropy between 0 and 1
Time frame: Time of the Inclusion
3D cartography difference of total sodium concentration between the iRBD and control subjects
total sodium concentration in mmol/L acquired with a specificic MRI coil
Time frame: Time of the Inclusion
3D cartography difference of structural brain connectivity between the iRBD and control subjects
A network-based statistics analysis will be performed: from Diffusion tensor imaging, a connectivity matrix will be populated for each subject. A t-test contrasting the two groups (iRBD and control subjects) will then be computed for each pairwise association. Finally, permutation testing will be used to ascribe a p-value controlled for the family-wise error rate to each connected component based on its size.
Time frame: Time of the Inclusion
Rate of Dependency between MRI parameters and demographic data
Pearson, Spearman or logistic regression, depending on the age and MRI parameters
Time frame: Time of the Inclusion
Rate of Dependency between MRI parameters and demographic data
Pearson, Spearman or logistic regression, depending on the sex and MRI parameters
Time frame: Time of the Inclusion
Rate of Dependency between MRI parameters and demographic data
Pearson, Spearman or logistic regression, depending on the laterality and MRI parameters
Time frame: Time of the Inclusion
Rate of Dependency between MRI parameters and demographic data, clinical scores/questionnaires
Pearson, Spearman or logistic regression, depending on the MDS-UPDRS I (Movement disorders society - Unified Parkinson's Disease Rating Scale) scale and MRI parameters
Time frame: Time of the Inclusion
Rate of Dependency between MRI parameters and clinical scores/questionnaires
Pearson, Spearman or logistic regression, depending on the MDS-UPDRS II scale and MRI parameters
Time frame: Time of the Inclusion
Rate of Dependency between MRI parameters and clinical scores/questionnaires
Pearson, Spearman or logistic regression, depending on the MDS-UPDRS III scale and MRI parameters
Time frame: Time of the Inclusion
Rate of Dependency between MRI parameters and clinical scores/questionnaires
Pearson, Spearman or logistic regression, depending on the SCOPA-AUT scale and MRI parameters
Time frame: Time of the Inclusion
Rate of Dependency between MRI parameters and clinical scores/questionnaires
Pearson, Spearman or logistic regression, depending on the HAD scale (Hospital Anxiety and Depression scale) and MRI parameters
Time frame: Time of the Inclusion
Rate of Dependency between MRI parameters and clinical scores/questionnaires
Pearson, Spearman or logistic regression, depending on the RBD (Rem sleep behaviour disorder) and MRI parameters
Time frame: Time of the Inclusion
Rate of Dependency between MRI parameters and demographic data, clinical scores/questionnaires
Pearson, Spearman or logistic regression, depending on the Pittsburgh sleep quality index and MRI parameters
Time frame: Time of the Inclusion
Rate of Dependency between MRI parameters and clinical scores/questionnaires
Pearson, Spearman or logistic regression, depending on the Starkstein motivation scale and MRI parameters
Time frame: Time of the Inclusion
Rate of Dependency between MRI parameters and clinical scores/questionnaires
Pearson, Spearman or logistic regression, depending on the non motor fluctuation scale and MRI parameters
Time frame: Time of the Inclusion
Rate of Dependency between MRI parameters and clinical scores/questionnaires
Pearson, Spearman or logistic regression, depending on the MoCA scale and MRI parameters
Time frame: Time of the Inclusion
Rate of Dependency between MRI parameters and clinical scores/questionnaires
Pearson, Spearman or logistic regression, depending on the phonemic and category fluencies and MRI parameters
Time frame: Time of the Inclusion
Rate of Dependency between MRI parameters and clinical scores/questionnaires
Pearson, Spearman or logistic regression, depending on the Benton judgement of lines and MRI parameters
Time frame: Time of the Inclusion
Rate of Dependency between MRI parameters and clinical scores/questionnaires
Pearson, Spearman or logistic regression, depending on the quality of life SF-36 and MRI parameters
Time frame: Time of the Inclusion
Rate of Dependency between MRI parameters and clinical scores/questionnaires
Pearson, Spearman or logistic regression, depending on the Miami Hallucinations questionnaire and MRI parameters
Time frame: Time of the Inclusion
Rate of Dependency between MRI parameters and clinical scores/questionnaires
Pearson, Spearman or logistic regression, depending on the treatement intake and MRI parameters
Time frame: Time of the Inclusion
Rate of Dependency between MRI parameters and clinical scores/questionnaires
Pearson, Spearman or logistic regression, depending on the blood pressure test and MRI parameters
Time frame: Time of the Inclusion
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