In this research study, the investigators are examining how brain activity (electrical and blood flow) changes during tests of emotional processing, attention and memory in the magnetic resonance imaging (MRI) scanner and outside the MRI using functional near-infrared spectroscopy (fNIRS). Investigators are also using non-invasive brain stimulation to probe different parts of the brain and measuring brain activity (electrical and blood flow). Study 1 This study includes healthy participants and researchers hope this will help us develop improved brain-based treatments for emotional difficulties like depression. Study 2 This study includes participants with depression and researchers hope this will help us develop improved brain-based treatments for emotional difficulties like depression.
Investigators hypothesize that targeted neuroplastic changes induced by individually-tailored rTMS will substantially reduce clinical symptoms underlying depression, anxiety and suicidality, and in general, revolutionize non-invasive treatments of mental health disorders. Investigators hypothesize that functional coupling in cognitive flexibility (CF) and emotion regulation (ER) networks is indexed by the phase of the brain's alpha oscillations. Using a novel integrated instrument that enables simultaneous functional magnetic resonance imaging (fMRI), electroencephalography (EEG) and transcranial magnetic stimulation (TMS), investigators propose to identify individualized stimulation parameters that reflect the strongest coupling of the CF/ER networks. Investigators will also use an instrument that enables simultaneous functional near-infrared spectroscopy (fNIRS), EEG, and TMS in attempt to identify the same parameters outside the scanner. The neuromechanistic model further posits that by applying repetitive TMS (rTMS) with these individualized parameters, one can induce entrainment in brain networks that drive neuroplastic changes in CF and ER. Study 1 This study is a proof-of-principle study in healthy control participants. Study 2 This study is a proof-of-principle study in participants with depression.
Study Type
OBSERVATIONAL
Enrollment
30
Participants will undergo a magnetic resonance imaging (MRI) scan with combined electroencephalography (EEG), and single-pulse transcranial magnetic stimulation (TMS) while completing cognitive flexibility (CF) and emotion recognition (CR) tasks.
Participants brain activity will be measured using functional near-infrared spectroscopy (fNIRS) with combined electroencephalography (EEG), and single-pulse transcranial magnetic stimulation (TMS) while completing cognitive flexibility (CF) and emotion recognition (CR) tasks.
Participants brain activity will be measured using functional near-infrared spectroscopy (fNIRS) with combined electroencephalography (EEG), and repetitive transcranial magnetic stimulation (rTMS). rTMS will be delivered via a MagVenture MagPro100 and Cool-B65 coil. The investigators will use a standard resting motor threshold (rMT) determination to determine the TMS dose. Treatment will be delivered at 120% of the motor threshold. The accelerated paradigm will consist 6 session a day for 5-6 days. Each rTMS session will be separated by 30 minutes of Cognitive Behavioral Therapy (CBT). rTMS treatment will be delivered at an individualized left DLPFC target based on each participant's individualized scans from prior neuroimaging sessions.
Medical Univeristy of South Carolina
Charleston, South Carolina, United States
RECRUITINGChange in reaction time (RT) tasks - Incongruent Stimuli
Tasks will be used to see differences between incongruent emotional stimuli.
Time frame: Day 1, Day 2, Day 3
Change in reaction time (RT) tasks - Congruent Stimuli
Tasks will be used to see differences between congruent emotional stimuli.
Time frame: Day 1, Day 2, Day 3
Change in reaction time (RT) tasks and accuracy - Incongruent Stimuli
Tasks will be used to see differences between incongruent emotional stimuli.
Time frame: Day 1, Day 2, Day 3
Change in reaction time (RT) tasks and accuracy - Congruent Stimuli
Tasks will be used to see differences between congruent emotional stimuli.
Time frame: Day 1, Day 2, Day 3
Clinical Improvement
25% reduction in Hamilton Score (HAMD) as a meaningful treatment response.
Time frame: Day 13, Day 18
Clinical Improvement
25% reduction in Passive and Active Suicidal Ideation Scale (PASIS) as a meaningful treatment response.
Time frame: Day 13, Day 18
Clinical Improvement
25% reduction in Patient Health Questionnaire (PHQ-9) as a meaningful treatment response.
Time frame: Day 13, Day 18
Clinical Improvement
25% reduction in Generalized Anxiety Disorder -7 Questionnaire (GAD7) as a meaningful treatment response.
Time frame: Day 13, Day 18
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