Thyroid Profiles in Patients With Acute Illness

Jordan Collaborating Cardiology Group

Overview

Patients admitted to the hospital with acute illness may have a wide spectrum of thyroid function abnormalities. It is largely unknown whether such aberrations are temporary or persist for a long time, and whether they impact prognosis of such patients.

Recently, there has been a growing body of evidence that subclinical thyroid dysfunction as a contributor to the increase of cardiovascular events. Elevated serum thyroid-stimulating hormone (TSH) levels and normal free thyroxine (FT4) and free triiodothyronine (FT3) levels have been associated with worse heart failure and dyslipidemia. Furthermore, higher risk of atrial fibrillation has been linked tp thyroid abnormalities in these patients. Patients admitted to the hospital with acute illness may have a wide spectrum of thyroid function abnormalities. It is largely unknown whether such aberrations are temporary or persist for a long time, and whether they impact prognosis of such patients. This study aimed at evaluating the prevalence of thyroid function abnormalities in patients admitted to hospital with acute illness and their temporal changes and impact on mortality during hospitalization and at 1 year. Serum level of thyroid stimulating hormone and free T4 and T3 measured on admission. Clinical and laboratory profiles of patients with abnormal thyroid function (ATF group) will be compared to those with normal thyroid function (NTF group). Short and long term survival of both groups were compares as well.

Study Type

OBSERVATIONAL

Conditions

Thyroid Dysfunction Acute Illness

Interventions

Performing blood thyroid test (TSH, FT4, FT3)OTHER

Blood test as above

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Hospital admission * Adults aged 18 years and above * Willing to sign an informed consent * Diagnosis on admission is acute illness that includes: heart failure, acute coronary syndrome, sepsis, acute stroke, hypotension, acute system-organ failure including renal and hepatic failure. Exclusion Criteria: * Age less than 18 years. * Refusal to sign consent. * Admission for a reason not classified as acute illness.

Locations (1)

Istishari Hospital

Amman, Jordan

Outcomes

Primary Outcomes

In hospital mortality

All-cause death rate in patients with abnormal thyroid function compared with death in those with no abnormal thyroid function during the patients hospital stay..

Time frame: From time of study entry until the date of death from any cause, assessed up to 2 weeks.

Secondary Outcomes

6-month mortality rate

All-cause death rate in patients with abnormal thyroid function compared with death in those with no abnormal thyroid function at 6 months.

Time frame: From date of study entry until the date of death from any cause, assessed up to two weeks.

Data from ClinicalTrials.gov

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