The goal of this clinical study is to investigate the effect of a curcuma longa oral gel (curenext) on reducing radiation-induced oral mucositis severity in cancer patients and provide a context for understanding if there is a relationship between the curcumin clinical effect and production of EGFs and IL8. Researchers will compare between curcumin group and standard treatment group.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
40
Curcuma longa oral gel for prevention radiation induced oral mucositis
Standard preparation for prevention radiation induced oral mucositis
Nuclear medicine and radiation therapy hospital
Baghdad, Iraq
Onset of radiation induced mucositis
Onset (at which week) of radiation induced mucositis in relation to EGF and IL8
Time frame: Assessment every week starting from first visit until the onset of mucositis (up to 2 months)
Change in severity of radiation induced mucositis
Change in severity (degree of illness) of radiation induced mucositis in relation to EGF \& IL-8 by World Health Organization (WHO) mucositis scale {0: no. 1: mild. 2 and 3 : moderate. 4: severe}
Time frame: Assessment every week starting from first visit of radiation unit it completion (average of 2 months)
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