Endogenous Lithium Clearance in Acute Kidney Injury

University Hospital of North Norway20 enrolled

Overview

Critically ill patients are at high risk of developing acute kidney injury (AKI). Lithium is freely filtrated at the glomerulus and almost completely reabsorbed in the proximal tubule, which provides a quantitative estimation of proximal tubule reabsorption. The investigators hypothesized that endogenous lithium reabsorption is impaired in the early stages of critical illness. Investigators would like to study 10 ICU patients with AKI diagnosed, 10 patients without AKI, and 10 healthy controls.

Blood and urine samples will be obtained at 08:00, 14:00 and 20:00 during one day. Renal clearance of creatinine (CCr) and lithium will be calculated.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Acute Kidney Injury Due to Sepsis Proximal Tubule Function Lithium Clearance

Interventions

Lithium clearanceDIAGNOSTIC_TEST

Blood and urine samples

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * ICU patients diagnosed with AKI, without AKI and healthy controls Exclusion Criteria: \-

Locations (1)

University Hospital of North Norway

Tromsø, Troms, Norway

Outcomes

Primary Outcomes

Renal lithium clearance

Clearance of lithium from the body

Time frame: 2 days

Data from ClinicalTrials.gov

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