IN10018 Combination Therapy in Previously-treated Solid Tumors

Inclusion Criteria: 1. Male or female aged 18-75 years old at the time of signing informed consent. 2. Be able to understand and be willing to sign informed consent. 3. Histologically or cytologically confirmed NSCLC, which is not suitable for locallly radical therapy. Note: Subjects should have received prior platinum-based doublet chemotherapy and anti-PD-1/L1-based systemic therapy and failed in treatment. 4. Subjects who have failed in 1- to 2 prior lines of standard systemic therapy. 5. Has at least one measurable tumor lesion per RECIST 1.1. 6. Has an ECOG performance status of 0 or 1. 7. Estimated life expectancy is more than 3 months. 8. Has adequate organ function. 9. AEs due to prior antitumor therapy must be recovered to ≤ Grade 1 (CTCAE v5.0) or a steady state as assessed by investigators 10. Subjects (male and female) with childbearing potential must agree to use contraception during the treatment phase and through 3 months after the last dose of study treatment. Exclusion Criteria: 1. Previously documented EGFR, ALK and ROS1 mutation. 2. Have received chemotherapy, biological therapy, endocrine therapy, immunotherapy and other antitumor drugs within 4 weeks prior to the first dose of study treatment. 3. Have received other antitumor investigational drugs or treatments within 4 weeks prior to the first dose of study treatment. 4. Have received radiotherapy within 14 days prior to the first dose of study treatment. 5. Have had allogeneic haematopoietic stem cell transplantation or organ transplantation. 6. History of autoimmune disease within the past 2 years. 7. Have an immunodeficiency disorder or have received systemic steroid therapy (prednisone or equivalent corticosteroid \> 10 mg/day) or other immunosuppressants within 7 days prior to the first dose of study treatment. 8. Currently have interstitial pneumonitis. 9. Have had FAK inhibitors treatment. 10. Have received prior nab-paclitaxel treatment and the first documented disease progression/recurrence is within 6 months since the last dose of nab-paclitaxel treatment. 11. Malignancies other than the study disease within 3 years prior to the first dose of study treatment. 12. Active central nervous system (CNS) metastases and/or carcinogenic meningitis. 13. Has a history of severe cardiovascular or cerebrovascular diseases within 6 months prior to the first dose. 14. Pleural, pericardial or abdominal effusion that are clinically symptomatic and require puncture or drainage. 15. Any active infection requiring systemic therapy within 14 days prior to the first dose of study treatment. 16. Has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the study. Note: Subjects who have experienced Grade ≥ 3 immuno-related AEs (irAEs) during prior immunotherapy will not be enrolled.