Effectiveness of Standard Therapy of Acne Vulgaris

Indonesia University724 enrolled

Overview

This study was to evaluate the effectiveness of standard therapy for acne vulgaris (AV) based on the clinical practice guidelines (CPG) in Indonesia. The main questions it aims to answer were: 1. How is the clinical characteristics of patients with AV in dr.Cipto Mangunkusumo Hospital? 2. How is the effectiveness of standard therapy for AV based on the CPG in Indonesia in reducing the number of non-inflammatory, inflammatory, and total lesions and degree of acne severity? The clinical pratice guideline (CPG) used for analysis was CPG by dr.Cipto Mangunkusumo Hospital 2017 in line with the date of patient visit. Data of 724 patients with AV in dr.Cipto Mangunkusumo Hospital as recorded in the medical records were assessed for eligibility. Data of 3-month-follow-up data of included subjects were collected and analyzed.

Objective: To evaluate the effectiveness of standard therapy for acne vulgaris (AV) based on the guidelines in Indonesia Design: An analytical retrospective observational study conducted from April 2023 through July 2023 using medical records of new acne patients between 2017 to 2019 from Dr. Cipto Mangunkusumo National Central General Hospital. A total sample of patients with AV who received standard therapy for acne vulgaris based on the guideline by Dr.Cipto Mangunkusumo Hospital in 2017 and not associated with systemic diseases or drugs were included. Patients were classified into mild, moderate, or severe acne using Lehmann grading system. Primary outcomes were changes in the number of non-inflammatory, inflammatory, and total lesions, and the proportion of acne severity after 3 months of therapy.

Study Type

OBSERVATIONAL

Enrollment

724

Conditions

Acne Vulgaris

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * New patients with acne vulgaris in the year 2017 to 2019 * Complete medical record data of 3-month follow-up, including data of: name, medical record number, sex, age, job, level of education, visit date, number of non-inflammatory, inflammatory, and total acne lesions, diagnosis of acne vulgaris based on Lehmann grading system * Acne treatment based on clinical practice guideline by dr.Cipto Mangunkusumo Hospital 2017 Exclusion Criteria: * Follow-up data less than 3 times in 3 months * Incomplete medical record * AV diagnosis without data on severity * History of systemic diseases associated with acne such as polycystic ovarian syndrome and Cushing syndrome * History of allergy with one or more standard acne therapy based on the clinical practice guideline * Received acne therapy not aligned with clinical practice guideline by dr.Cipto Mangunkusumo Hospital

Outcomes

Primary Outcomes

Change in non-inflammatory acne lesion count

Change in the sum of the number of open and closed comedones

Time frame: week-12

Change in inflammatory acne lesion count

Change in the sum of the number of papules, pustules, nodes, and cysts

Time frame: week-12

Change in total acne lesioncount

Change in the sums of the number of non-inflammatory and inflammatory lesions

Time frame: week-12

Change in acne severity

Change in the acne severity based on Lehmann grading system (2002), which classified acne into mild, moderate, and severe

Time frame: week-12

Effectiveness of Standard Therapy of Acne Vulgaris

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes