Steroid Injection for Sickle Cell Arthropathy Pain Therapy

Salem Anaesthesia Pain Clinic50 enrolled

Overview

Sickle cell disease (SCD) is associated with arthropathy. Arthropathy may require periarticular corticosteroid injection therapy. This observational study examines efficacy, and safety of steroid injections in SCD patients. Data collection includes patient's gender, age, race, smoking history, alcohol intake, analgesic use, pain score, sleep quality, limb joint injections, post-injection analgesia, and post-injection complication. Pain is measured using numeric pain scale. Sleep quality is measured using Likert scale.

Sickle cell disease (SCD) is associated with arthropathy. Arthropathy causes pain which may require periarticular corticosteroid injection therapy. There is inadequate data about the suitability of steroid therapy in SCD patients. This prospective observational study examines the efficacy, and safety of periarticular steroid injections in SCD patients. This is a cohort study of adult patients undergoing pain management at a pain clinic in Canada. Data collection includes patient's gender, age, race, smoking history, alcohol intake, analgesic usage, numeric pain score, sleep quality score, limb joint injections, post-injection analgesia, and post-injection complication. Pain is measured using numeric pain rating scale. Sleep quality is measured using the Likert Sleep scale. A change in the pain or sleep scores by 2-points is considered significant. Data are analyzed with IBM® SPSS® Statistics 25; using Student's t-test, ANOVA, Pearson Chi-square test, and regression analysis. P-value \<0.05 is considered significant.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Sickle Cell Disease Sickle Cell Abnormality

Interventions

Dexamethasone 20mgDRUG

Periarticular dexamethasone injection

Eligibility

Sex: ALLMin age: 20 YearsMax age: 99 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * adult chronic pain patients * sickle cell disease arthropathy * periarticular steroid injection therapy * regular sleep diary * regular pain diary * informed consent for therapy and diary review Exclusion Criteria: * pediatric patients * patient without sickle cell disease arthropathy * patient without periarticular steroid injection * irregular sleep diary * irregular pain diary

Locations (1)

Salem Anaesthesia Pain Clinic

Surrey, British Columbia, Canada

Outcomes

Primary Outcomes

Numeric pain score, objective measurement using validated Numeric Pain Rating scale

Pain score, using the Numeric Pain Rating scale of 0 to 10, low scores indicate less pain, high scores indicate worse pain

Time frame: 12 weeks

Secondary Outcomes

Sleep quality score, objective measurement using validated Likert sleep scale

Sleep quality score, using the Likert sleep scale of 0 to 10, low scores indicate poor sleep, high scores indicate better sleep

Time frame: 12 weeks

Data from ClinicalTrials.gov

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