Robotic Hand Rehabilitation

Modified Fatigue Impact Scale (MFIS)

The MFIS is an instrument that provides an assessment of the effects of fatigue in terms of physical, cognitive, and psychosocial functioning. The full-length MFIS consists of 21 items while the abbreviated version has 5 items. The MFIS is a structured, self-report questionnaire that the patient can generally complete with little or no intervention from an interviewer. However, patients with visual or upper extremity impairments may need to have the MFIS administered as an interview. Interviewers should be trained in basic interviewing skills and in the use of this instrument. The total score for the MFIS is the sum of the scores for the 21 items. Individual subscale scores for physical, cognitive, and psychosocial functioning can also be generated by calculating the sum of specific sets of items.

Time frame: Change from Baseline MFIS at 4 weeks

Fatigue Scale for Motor and Cognitive Function (FSMC)

The FSMC is an assessment of MS-related cognitive and motor fatigue. A Likert-type 5-point scale (ranging from 'does not apply at all' to 'applies completely') produces a score between 1 and 5 for each scored question. Thus minimum value is 20 (no fatigue at all) and maximum value is 100 (severest grade of fatigue). Two subscales (mental and physical fatigue) can be made. Items included in the subscale mental are 1-4-7-8-11-13-15-17-18-20 and items included in the subscale physical are 2-3-5-6-9-10-12-14-16-19.

Time frame: Change from Baseline FSMC at 4 weeks

The Medical Research Council (MRC) Scale

The MRC Scale is a 6-value scale for measuring strength through the observation of movement and muscle behaviour for grades 0 to 3 and the administration of Manual Muscle Tests for grades 4 and 5. The MRC Scale provides a score ranging from 0 to 5: 0 Absence of contraction 1. Hint of muscle contraction 2. Active movement that eliminates the force of gravity 3. Active movement against the force of gravity 4. Active movement against the force of gravity and a resistance 5. Normal force

Time frame: Change from Baseline MRC at 4 weeks

Motricity Index - Upper Limb (MI-UL)

MI-UL can be used to assess the upper limb motor impairment in a patient who has had a stroke. Test for each upper limb: pincer grip elbow flexion shoulder abduction For the pincer grip: 0 points, no movement 19 points, grip possible but not against gravity 33 points, normal grip For all other items: 0 points, no movement 14 points, Visible movement but not for the entire joint range or against gravity 19 points, movement possible for the entire joint range against gravity but not against resistance 33 points movement performed with normal force Each segment has a total score obtained by adding the value "1" to the score of each individual item. The total score then ranges from 1 (no movement) to 100 (normal movement).

Time frame: Change from Baseline MI-UL at 4 weeks

Stroke Upper Limb Capacity Scale (SULCS)

The SULCS is a scale that assesses various arm and hand skills in the hemiplegic patient; in particular, it assesses highly functional movements related to activities of daily living. It consists of 10 items, assessable with a score of 0 or 1 (not performed/executed correctly), of which 3 items for limb skills without hand activity 4 items for limb skills and simple hand skills 3 items for complex hand skills The SULCS is a hierarchical scale: if the patient has poor upper limb skills and is unable to perform 3 consecutive items, all subsequent items will automatically receive a score of 0 without having to be performed. The maximum scale score is 10.

Time frame: Change from Baseline SULCS at 4 weeks

9-Hole Peg test (9HPT)

The 9HPT is used to measure finger dexterity. The patient is asked to take the pegs from a container, one by one, and insert them into the holes in the board, as quickly as possible, using only his hand to assess. He/she must then remove them, one at a time, and reinsert them into the container. The final score is given by the time it takes the patient to complete the test.

Time frame: Change from Baseline 9HPT at 4 weeks

Box&Block test (BBT)

The BBT) measures unilateral gross manual dexterity. It is a quick, simple and inexpensive test. The BBT consists of a wooden box divided into two compartments by a divider and 150 blocks. The administration of the BBT consists of asking the patient to move, one at a time, the maximum number of blocks from one compartment of the box to another of equal size, within 60 seconds. The test must begin with the upper limb unaffected. The score is given according to the number of blocks moved from one compartment to another in 60 seconds. The score is assigned to each hand separately. Higher scores indicate better manual dexterity.

Time frame: Change from Baseline BBT at 4 weeks

Modified Ashworth Scale (MAS)

It is performed by first extending the patient's limb from a position of maximum possible flexion to maximum possible extension. The score ranges from 0 to 4: 0 No increase in tone 1 Slight increase in tone, giving a signal when there is a slight increase in muscle tone, manifested when the limb is moved into flexion or extension. 1+ slight increase in muscle tone, manifested by a jerk followed by minimal resistance throughout the movement (ROM) 2 more marked increase in tone, but more marked increase in muscle tone through most of the limb easily flexed 3 marked increase in tone, difficult passive movement 4 stiff limb in flexion or extension

Time frame: Change from Baseline MAS at 4 weeks

HandGrip Test (HGT)

HGT is a test performed with a dynamometer, which goes to assess muscle strength (in kilograms). Starting with the elbow flexed to 90°, the patient must squeeze the dynamometer as hard as they can at one time. Three repeated measurements are taken on each side 20 seconds apart. The average of the three assessments is used as the final value.

Time frame: Change from Baseline HGT at 4 weeks

modified Barthel Index (mBI)

mBI for activities of daily living is meant to be used in the assessment of patient performance (or degree of assistance required) with respect to self-care, sphincter management, transfers and locomotion. The index consist of 10 items (each scored with a number of points) that relate to activities of daily living (ADLs) where the final score is calculated by summing the points awarded to each item. A five-point rating scales for each item to improve sensitivity to detecting change. The 10 items assessed relate to: Help needed with feeding; Help needed with bathing; Help needed with grooming; Help needed with dressing; Presence or absence of fecal incontinence; Presence or absence of urinary incontinence; Help needed with transfers; Help needed with walking; Help needed with climbing stairs. Interpretation: 91-100 Slight dependency 61-90 Moderate dependency 21-60 Severe dependency 0-20 Total dependency

Time frame: Change from Baseline mBI at 4 weeks

EuroQol- 5 Dimension (EQ-5D)

EQ-5D is an instrument which evaluates the generic quality of life. The EQ-5D descriptive system is a preference-based HRQL measure with one question for each of the five dimensions that include mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. The answers given to ED-5D permit to find 243 unique health states or can be converted into EQ- 5D index an utility scores anchored at 0 for death and 1 for perfect health.

Time frame: Change from Baseline EQ-5D at 4 weeks